Results 61 to 70 of about 12,667 (213)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Reaching Function Analysis of Water Quality and Protecting Measure in Water Supply Sources ——Taking Liuzhou City as an Example

Shuitu baochi yanjiu, 2007
Water quality model can simulate and predict the moving and diffusing law of the pollutant in water body.It is a common method to study and settle the problem of polluted water.A 2-D FVM and Riemann approximate solution model for water quality of the ...
YAN Run-run, PANG Yong
doaj  

Curvas de permanência de qualidade da água como subsídio para o enquadramento de corpos d'água a partir de modelagem matemática em regime não permanente

RBRH
RESUMO Modelos matemáticos de qualidade de água têm sido utilizados como ferramentas para o planejamento e a gestão de recursos hídricos em diversos países. Em geral, em rios, as análises são baseadas em simulações considerando condições de escoamento de
Danieli Mara Ferreira, Cristovão Vicente Scapulatempo Fernandes, Eloy Kaviski   +2 more
doaj   +1 more source

Hydrologic and Water Quality Model Development Using Simulink

Journal of Marine Science and Engineering, 2014
A stormwater runoff model based on the Soil Conservation Service (SCS) method and a finite-volume based water quality model have been developed to investigate the use of Simulink for use in teaching and research.
James D. Bowen, David N. Perry, Colin D. Bell   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Proposal of a methodology for pre-selection of sewage treatment systems within watersheds

RBRH
The selection of sewage treatment plants within watersheds is a complex process when there are multiple outflows presenting different loads and watercourses presenting different assimilation capabilities.
Lucas Luiz Dall'Orto Fantin, José Antonio Tosta dos Reis, Antonio Sérgio Ferreira Mendonça   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The role of optimizers in developing data-driven model for predicting lake water quality incorporating advanced water quality model

Alexandria Engineering Journal
Lake water is considered as one of the most precious freshwater resources for human consumption and thus, it is required to monitor the lake water quality (WQ) to maintain the good water state.
Md Galal Uddin, Apoorva Bamal, Mir Talas Mahammad Diganta, Abdul Majed Sajib, Azizur Rahman, Mohamed Abioui, Agnieszka I. Olbert   +6 more
doaj   +1 more source