Results 61 to 70 of about 834,737 (262)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Proposal of a methodology for pre-selection of sewage treatment systems within watersheds

RBRH
The selection of sewage treatment plants within watersheds is a complex process when there are multiple outflows presenting different loads and watercourses presenting different assimilation capabilities.
Lucas Luiz Dall'Orto Fantin, José Antonio Tosta dos Reis, Antonio Sérgio Ferreira Mendonça   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Performance indicators model assessment for water system quality and supply in Montenegro [PDF]

Journal of the Serbian Chemical Society
The paper researches water quality, supply and management system assessment problems of the Montenegrin costal region. A significant problem is generated by seasonal tourism, the main branch of Montenegrin costal economy.
Doklestić Olivera, Vojinović-Miloradov Mirjana, Elezović Nataša, Kolaković Srđan, Simeunović Nenad   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The role of optimizers in developing data-driven model for predicting lake water quality incorporating advanced water quality model

Alexandria Engineering Journal
Lake water is considered as one of the most precious freshwater resources for human consumption and thus, it is required to monitor the lake water quality (WQ) to maintain the good water state.
Md Galal Uddin, Apoorva Bamal, Mir Talas Mahammad Diganta, Abdul Majed Sajib, Azizur Rahman, Mohamed Abioui, Agnieszka I. Olbert   +6 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

A coupled hydrodynamic (HEC-RAS 2D) and water quality model (WASP) for simulating flood-induced soil, sediment, and contaminant transport. [PDF]

J Flood Risk Manag, 2021
Shabani A, Woznicki SA, Mehaffey M, Butcher J, Wool TA, Whung PY.   +5 more
europepmc   +1 more source

Integral water quality modelling of catchments

Water Science and Technology, 2001
ESWAT - Extended Soil and Water Assessment Tool - was developed to allow for an integral modelling of the water quantity and quality processes in river basins. The diffuse pollution sources are assessed by considering crop and soil processes and - together with the point sources - further transformed by an in-stream water quality module.
Van Griensven, Ann, Bauwens, Willy
openaire   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source