Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Modified zeolites in ground water treatment [PDF]
, 2015 There are presented results of technological experiments carried out in Water Treatment Plant Kúty. The goal of this study was to compare modified zeolite known as clinoptilolite (rich deposits of clinoptilolite were found in the region of East Slovakia ...
Barloková, Danka +2 more
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Magnesium Salt Recovery from Concentrate and Use in Treatment of Saline Water [PDF]
E3S Web of ConferencesMagnesium salt was recovered from artificial concentrate and used in the removal of contaminants (PO4, Turbidity and NO3) from saline water that has high initial magnesium concentration (artificial brackish and sea water) at pH 11. Solar panels were used
Al-Momani Tuqa, Ammary Bashaar
doaj +1 more source
Elucidating two-phase transport in a polymer electrolyte fuel cell, Part 1: Characterizing flow regimes with a dimensionless group [PDF]
, 2011 This paper explores the through-/in-plane characteristics of water transport in the cathode gas diffusion layer (GDL) of a polymer electrolyte fuel cell (PEFC). Theoretical analysis is performed on the non-isothermal two-phase flow under flow channels. A
Chen, KS, Wang, Y
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Bioaugmentation mitigates the impact of estrogen on coliform-grazing protozoa in slow sand filters [PDF]
, 2016 Exposure to endocrine-disrupting chemicals (EDCs), such as estrogens, is a growing issue for human and animal health as they have been shown to cause reproductive and developmental abnormalities in wildlife and plants and have been linked to male ...
Collins, Gavin +3 more
core +10 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Ion Exchange for Nutrient Recovery Coupled with Biosolids-Derived Biochar Pretreatment to Remove Micropollutants [PDF]
, 2018 Wastewater, especially anaerobic treatment effluent, contains high ammonia nitrogen (NH4-N) and inorganic orthophosphate (PO4-P), which necessitate additional treatment to meet stringent discharge regulations.
Avila, Anna +4 more
core +1 more source
Arsenic in drinking water wells on the Bolivian high plain: field monitoring and effect of salinity on removal efficiency of iron-oxides-containing filters [PDF]
, 2010 In the rural areas around Oruro (Bolivia), untreated groundwater is used directly as drinking water. This research aimed to evaluate the general drinking water quality, with focus on arsenic (As) concentrations, based on analysis of 67 samples from about
De Deckere, E +4 more
core +1 more source