Results 71 to 80 of about 5,911,663 (289)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Water in the 2006 Virginia General Assembly
, 2006 The 2006 Virginia General Assembly convened January 11 and adjourned March 11, with a reconvened (“veto”) session on April 19. The legislature considered 3287 measures; among the most important business was development of the biennial state budget. Below
Virginia Water Resources Research Center
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Water-Related Bills in the 2008 Virginia General Assembly
, 2008 The 2008 Virginia General Assembly session opened January 9 and adjourned March 13. Work on the biennial state budget required a few additional days beyond the scheduled adjournment date of March 8.
Virginia Water Resources Research Center
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Water in the 2001 General Assembly
, 2001 The 2001 Virginia General Assembly lasted from January 10 to February 24. The House of Delegates and Senate considered 2645 bills and resolutions. By our reckoning, 123 of these had something to do with water resources or water-related activities.
Virginia Water Resources Research Center
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Volume of Water Bills in the 1999 Virginia General Assembly
, 1999 The Virginia General Assembly held its 1999 session from January 13 to February 27. During the regular session, lawmakers considered 2,735 bills and resolutions, compared to 2945 measures considered in the longer 1998 session.
Virginia Water Resources Research Center
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
1998 General Assembly Legislation Related to Water
, 1998 The Virginia General Assembly held its regular session from January 14 to March 17, then reconvened April 22-23 to respond to the governor’s vetoes.
Manfre, Joseph +1 more
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