Results 41 to 50 of about 1,038,545 (295)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structure and Properties of the Xerogels Based on Potassium Silicate Liquid Glass and Urea

Molecules, 2023
The xerogels based on the aqueous solutions of urea in potassium silicate liquid glass (PSLG) were produced by CO2 bubbling and investigated. The structure and chemical composition of the obtained materials were analyzed.
Alexander Gorokhovsky, Igor Burmistrov, Denis Kuznetsov, Alexander Gusev, Bekzod Khaidarov, Nikolay Kiselev, Elena Boychenko, Evgeny Kolesnikov, Ksenia Prokopovich, Yuri Konyukhov, Maksim Kravchenko   +10 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effect of silt modification on the properties of magnesium phosphate cement

Frontiers in Materials, 2023
Magnesium phosphate cement (MPC), as a new type of cementitious material, is difficult to be popularized in practical applications due to its short setting time, high cost, and poor water resistance.
Haikuan Wang, Zhitang Li, Qiling Luo, Wujian Long   +3 more
doaj   +1 more source

Antibiotic-resistant bacteria in drinking water [PDF]

Applied and Environmental Microbiology, 1981
We analyzed drinking water from seven communities for multiply antibiotic-resistant (MAR) bacteria (bacteria resistant to two or more antibiotics) and screened the MAR bacterial isolates obtained against five antibiotics by replica plating. Overall, 33.9% of 2,653 standard plate count bacteria from treated drinking waters were MAR.
J L, Armstrong, D S, Shigeno, J J, Calomiris, R J, Seidler   +3 more
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Combined Effects of Linseed Oil and Heat Treatment on the Properties of Cypress and Maple Wood Part 1: Water Absorption, Mechanical Properties, and Sound Absorption Capacity

BioResources, 2023
The physical and mechanical properties of thermally modified wood impregnated with linseed oil were investigated to find the relationship between the treatment and the acoustic properties. The samples were impregnated with linseed oil (LO).
Ali Ihsan Kaya
doaj  

An Overview of Grease Water Resistance

Lubricants, 2020
Many grease-lubricated components operate in wet environments, making them susceptible to water contamination which degrades their performance, functionality, and useful life. Hence, selecting a grease with appropriate water-resistant properties can have
Alan Gurt, Michael Khonsari
doaj   +1 more source

Antibiotic-Resistance Genes in Waste Water [PDF]

Trends in Microbiology, 2018
Waste water and waste water treatment plants can act as reservoirs and environmental suppliers of antibiotic resistance. They have also been proposed to be hotspots for horizontal gene transfer, enabling the spread of antibiotic resistance genes between different bacterial species.
Karkman, Antti, Do, Thi Thuy, Walsh, Fiona, Virta, Marko P.J.   +3 more
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source