Results 81 to 90 of about 12,262,922 (372)
Water Resources Research, 2020 Climate change introduces substantial uncertainty to water resources planning and raises the key question: when, or under what conditions, should adaptation occur? A number of recent studies aim to identify policies mapping future observations to actions—
J. Herman +4 more
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
AgronomyThe control of irrigation volume is of significant importance in arid regions of northwest China. Particularly, it has a crucial impact on the salinization of shallow groundwater areas.
Changfu Tong +3 more
doaj +1 more source
Remote Sensing, 2020 Climate variability and recurrent droughts have caused remarkable strain on water resources in most regions across the globe, with the arid and semi-arid areas being the hardest hit.
Trisha Deevia Bhaga +3 more
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
AgronomyDroughts are long-term natural disasters and encompass many unknown factors. Herein, yearly and seasonal standardized precipitation evapotranspiration index (SPEI) values were calculated by analyzing monthly temperature and precipitation data from 1971 ...
Sinan Wang +4 more
doaj +1 more source
A basic review of fuzzy logic applications in hydrology and water resources
Applied Water Science, 2020 In recent years, fuzzy logic has emerged as a powerful technique in the analysis of hydrologic components and decision making in water resources. Problems related to hydrology often deal with imprecision and vagueness, which can be very well handled by ...
Shruti Kambalimath, P. Deka
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source