Results 31 to 40 of about 296,208 (259)

Effects of precipitation and potential evaporation on actual evapotranspiration over the Laohahe basin, northern China [PDF]

Proceedings of the International Association of Hydrological Sciences, 2015
Problems associated with water scarcity are facing new challenges under the climate change. As one of main consumptions in water cycle on the Earth, evapotranspiration plays a crucial role in regional water budget. In this paper, we employ two methods,
Y. Liu, L. Ren, X. Yang, M. Ma, F. Yuan, S. Jiang   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Review.Water resources deficit and water engineering

Spanish Journal of Agricultural Research, 2010
The increasing demand of water for different uses, together with the variable availability of this resource, which is due to the increasingly frequent periods of drought, make necessary to undertake a set of structural and contextual actions to cope with the permanent or temporary scarcity situations.
Tarjuelo, J. M., De-Juan, J. A., Moreno, M. A., Ortega, J. F.   +3 more
openaire   +4 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Multistep Wind Speed Prediction Based on the Fractional-Order Longicorn Swarm Algorithm and the Two-Stage Modal Decomposition Strategy

Journal of Electrical and Computer Engineering
Least squares support vector machine (LSSVM) and variational mode decomposition are common research methods for wind speed time series prediction. Addressing the challenge of selecting relevant parameters of LSSVM and VMD, a fractional-order Beetle swarm
Shuren Pu, Yuanchen Gao, Yifeng Sun, Chang Liu, Siyu He, Fengjiao Wu, Delan Zhu, Bin Wang   +7 more
doaj   +1 more source

Estimation and Assessment of the Root Zone Soil Moisture from Near-Surface Measurements over Huai River Basin

Atmosphere, 2023
Root zone soil moisture (RZSM) is a vital variable for agricultural production, water resource management and runoff prediction. Satellites provide large-scale and long-term near-surface soil moisture retrievals, which can be used to estimate RZSM ...
En Liu, Yonghua Zhu, Haishen Lü, Robert Horton, Qiqi Gou, Xiaoyi Wang, Zhenzhou Ding, Haiting Xu, Ying Pan   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Application of neuro-genetic algorithm to determine reservoir response in different hydrologic adversaries

Soil and Water Research, 2009
The hydrologic adversaries like high magnitude storms, extreme dryness, aridity, more than normal demand for water etc. often cause a huge stress on the storage structures such as reservoirs and check dams. This stress implies a lot of adverse effects on
Mrinmoy Majumder, Rabindra Nath Barman, Pankaj Kr. Roy, Bipal Kr. Jana, Asis Mazumdar   +4 more
doaj   +1 more source