Results 51 to 60 of about 1,913,279 (336)

Modeling of the water resources nature-engineering system [PDF]

, 2013
Обґрунтовано методологію і методи оцінювання гідроекологічної безпеки природно-техногенних екосистем та запропонована модель взаємозв’язку гідроекосистеми і природних ресурсів.
Trysnyuk, V., Триснюк, Василь Миколайович   +1 more
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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Application of neuro-genetic algorithm to determine reservoir response in different hydrologic adversaries

Soil and Water Research, 2009
The hydrologic adversaries like high magnitude storms, extreme dryness, aridity, more than normal demand for water etc. often cause a huge stress on the storage structures such as reservoirs and check dams. This stress implies a lot of adverse effects on
Mrinmoy Majumder, Rabindra Nath Barman, Pankaj Kr. Roy, Bipal Kr. Jana, Asis Mazumdar   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Multistep Wind Speed Prediction Based on the Fractional-Order Longicorn Swarm Algorithm and the Two-Stage Modal Decomposition Strategy

Journal of Electrical and Computer Engineering
Least squares support vector machine (LSSVM) and variational mode decomposition are common research methods for wind speed time series prediction. Addressing the challenge of selecting relevant parameters of LSSVM and VMD, a fractional-order Beetle swarm
Shuren Pu, Yuanchen Gao, Yifeng Sun, Chang Liu, Siyu He, Fengjiao Wu, Delan Zhu, Bin Wang   +7 more
doaj   +1 more source

Dam Breach Modeling and Downstream Flood Inundation Mapping Using HEC-RAS Model on the Proposed Gumara Dam, Ethiopia

Advances in Civil Engineering, 2023
This study was, therefore, taken up to dam breach modeling and downstream flood inundation mapping. To achieve this objective, the software ArcGIS Version 10.4 extension program of HEC-GeoRAS Version 10 tool was used for HEC-RAS model development, to ...
Manamno Beza, Amdeselassie Fikre, Alene Moshe   +2 more
doaj   +1 more source

Review.Water resources deficit and water engineering

Spanish Journal of Agricultural Research, 2010
The increasing demand of water for different uses, together with the variable availability of this resource, which is due to the increasingly frequent periods of drought, make necessary to undertake a set of structural and contextual actions to cope with the permanent or temporary scarcity situations.
Tarjuelo, J. M., De-Juan, J. A., Moreno, M. A., Ortega, J. F.   +3 more
openaire   +4 more sources

Assessing the risk of groundwater contamination from hazardous-waste management (1995) [PDF]

, 1995
"New 10/95/3M.""Water Quality.""Farm-A-Syst : Farmstead Assessment System. Worksheet #5. ""Published by University Extension. University of Missouri-Columbia.""The Missouri Farmstead Assessment System is a cooperative project of University Outreach and ...
University Extension, University of Missouri-System
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