Results 101 to 110 of about 1,808,636 (336)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

PARTICULARITY ON LIQUID CHROMATOGRAPHIC SEPARATION FOR AN EQUIMOLAR MIXTURE OF 2,4-DINITROPHENYLHYDRAZONES PROVIDED BY ACETALDEHYDE AND DIACETYL

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
An equimolar mixture of 2,4-dinitrophenylhidrazones (2,4-DNPH-ones) providing by acetaldehyde and diacetyl has been analyzed by liquid-chromatographic separation, using the mechanism of partition with reverse phase.
Gheorghe Zgherea, Cristina Stoian, Sandu Peretz   +2 more
doaj  

Pilot scale study of chlorination-induced transport property changes of a seawater reverse osmosis membrane [PDF]

, 2013
A pilot-scale study was performed to assess variations of reverse osmosis (RO) membrane water permeance (A) and salt retention (Robs) induced by chlorination and to compare them with those observed at the lab-scale. A chlorination protocol was adapted to
Akdag, Arthur, Avlonitis, Axel Ettori, Benavente, Cadotte, Christel Causserand, Chung, Dam, Do, Emmanuelle Gaudichet-Maurin, Ettori, Ettori, Gabelich, Geise, Glater, Glater, Glater, Kang, Knoell, Koo, Koo, Kwon, Kwon, Kwon, Maruf, Mitrouli, Nilsson, Pierre Aimar, Pope, Scofield, Shemer, Soice, Subramani, Tang, Tang, von Gunten   +36 more
core   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Impact of soil texture on biosurfactant‐mediated soil wetting and water retention

Agricultural & Environmental Letters
Increasing global food demand combined with more frequent and intense periods of drought necessitates new strategies to improve agricultural water use efficiency.
Moises M. Gutierrez, Silvio C. Liu, Shahnawaz Alam Dip, Ganga M. Hettiarachchi, Melanie M. Derby, Ryan R. Hansen   +5 more
doaj   +1 more source

Mix proportion optimization of cement flyash-water glass grouting material based on response surface method [PDF]

AIP Advances
In the process of tunnel construction and operation, fissure water inrush disasters occur frequently, seriously threatening the safety and construction efficiency of the project.
Tong Wu, Xue Yang, Jianghong Xu
doaj   +1 more source

Simulasi Kolam Retensi untuk Mengatasi Banjir Genangan di Kota Bangkinang Bagian Barat [PDF]

, 2014
Most of the surface run off water in rainy season in Bangkinang flow to Petai I river, and this condition makes the Petai I river unable to deliver it anymore to Kampar river, it will flood some region in Bangkinang.
Mudjiatko, M. (Mudjiatko), Rachman, B. A. (Bangun), Trimaijon, T. (Trimaijon)   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Ice formation in unsaturated frozen soils [PDF]

, 2018
This paper presents a procedure for determining unfrozen water saturation in a partially saturated frozen soil (clayey silt) using bulk electrical conductivity (EC) measurements.
Gens Solé, Antonio, Mao, Yanxin, Romero Morales, Enrique Edgar   +2 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source