Results 31 to 40 of about 7,774,898 (298)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Advances in Mechanical Engineering, 2019 Road alignment, traffic flow, and sign information interact and create complex traffic situations. To evaluate the effects of freeway horizontal radius, slope grade, traffic flow, and sign information on subjective driving workload and performance, a ...
Lian Xie +3 more
doaj +1 more source
Frontiers in Sports and Active Living, 2023 BackgroundIt is desirable that (more) children continue swimming after having completed their swimming lessons to preserve their swimming skills and water safety, and as part of an active, healthy lifestyle.
Carola Minkels +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
National Water Safety Forum – ‘working together for water safety’ [PDF]
Injury Prevention, 2010 This presentation considers the challenges and achievements within the UK National Water Safety Forum (NWSF), and in particular through the development of its critical project; the Water Accident Incident Database (WAID). A Government review that considered roles and responsibilities for inland water safety in 2003 offered two key recommendations: (i ...
openaire +1 more source
Editorial: Microbial Safety in Water Resources [PDF]
Frontiers in Microbiology, 2018 Funding: This work is partly supported by KAUST Baseline funding BAS/1/1033-01-01 awarded to P-YH.
Pei-Ying Hong +4 more
openaire +5 more sources
Frontiers in Earth Science, 2022 A major justification for building the Three Gorges Dam on the Changjiang is flood control. The dam can reduce peak discharge during severe floods. These floods, however, cannot be prevented by operation of the Three Gorges Dam alone.
David Shankman, Xijun Lai
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Performance of traditional household drinking water treatment methods used in rural Amazon
Frontiers in WaterResidents of remote areas in the Amazon often lack access to a water supply system and thus need to produce their potable water at home. This study examined the efficacy of household water treatments traditionally used by these communities to treat ...
Maria Cecilia Rosinski Lima Gomes +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source