Results 41 to 50 of about 2,341,229 (357)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Prioritization methodology for roadside and guardrail improvement: Quantitative calculation of safety level and optimization of resources allocation [PDF]
, 2018 The attention to road safety-related issues has grown fast in recent decades. The experience gained with these themes reveals the importance of considering these aspects in the resource allocation process for roadside and guardrail improvement, which is ...
Cantisani, Giuseppe +3 more
core +1 more source
Nanomaterials, 2023 Amino- and carboxyl-functionalized carbon quantum dots (Amino-CQDs) were synthesized through fast and simple microwave treatment of a citric acid, ethylenediamine and ethylenediaminetetraacetic acid (EDTA) mix.
Anastasia Yakusheva +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Microfluidic Devices for Heavy Metal Ions Detection: A Review
Micromachines, 2023 The contamination of air, water and soil by heavy metal ions is one of the most serious problems plaguing the environment. These metal ions are characterized by a low biodegradability and high chemical stability and can affect humans and animals, causing
Myrto-Kyriaki Filippidou +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Performance of traditional household drinking water treatment methods used in rural Amazon
Frontiers in WaterResidents of remote areas in the Amazon often lack access to a water supply system and thus need to produce their potable water at home. This study examined the efficacy of household water treatments traditionally used by these communities to treat ...
Maria Cecilia Rosinski Lima Gomes +7 more
doaj +1 more source
Horticultural assessment scheme: insight in prevalence and distribution of microbial contamination to evaluate water management in fresh produce processing industry [PDF]
, 2011 Title: Horticultural Assessment Scheme: insight in prevalence and distribution of microbial contamination to evaluate water management in fresh produce processing industry. Introduction: Microbial food safety is a global concern.
Holvoet, Kevin +3 more
core +2 more sources