Results 61 to 70 of about 7,774,898 (298)

Safety guidelines for copper in water [PDF]

The American Journal of Clinical Nutrition, 1998
It is important for public health authorities to set a scientifically sound guideline value for the safe ingestion of copper in drinking water. To date, the principal health-based guideline values have been set by the US Environmental Protection Agency (1.3 mg Cu/L) and the World Health Organization (2.0 mg Cu/L). However, close examination of the data
openaire   +2 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Catastrophic dam failures under climate change: characteristics, mechanisms, and climate-adaptive strategies

Shuili Shuiyun Gongcheng Xuebao
In the context of the increasingly severe global challenge of climate change, the frequent occurrence of extreme weather events and the intensification of human activities are becoming increasingly intertwined.
LIU Liuyan, LI Hongen, ZHOU Ning, WANG Xuebing, WANG Fang, ZHANG Zhu   +5 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Securing executive buy-in for preventative risk management - lessons from water safety plans [PDF]

, 2011
Appropriate implementation of water safety plans (WSPs) offers an important opportunity to engage in and promote preventative risk management within water utilities.
Smith, Jennifer A., Williams, T., Breach, B., Summerill, Corinna, Pollard, Simon J. T.   +4 more
core   +1 more source

Environmental Education and water consumption in homes in rural areas [PDF]

Brazilian Journal of Biology
Water is a basic resource for the survival of human beings, however, not everyone has access to this resource and they look for ways to survive under unfavorable conditions; for this purpose, environmental education focused on water safety consumption is
R. Yaulilahua-Huacho, J. L. Huere-Peña, C. Dueñas-Jurado, L. A. Sumarriva-Bustinza, C. Castañeda-Campos, J. L. Gave-Chagua, E. J. Ccente-Chancha, M. A. Martínez-Cáceres, J. C. Ayuque-Rojas, M. Castrejon-Valdez, N. L. Chávez Sumarriva   +10 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Water Rescue and Safety: Child Drowning Prevention and Water Safety Education

European Journal of Arts, Humanities and Social Sciences
Child drowning remains one of the most underestimated yet preventable public health threats worldwide, particularly in low- and middle-income countries. This article offers a comprehensive analysis of child drowning prevention strategies and the development of effective water safety education systems.
No, Sinath, Sam, Rany, Chan, Sokha, Hour, Ry   +3 more
openaire   +1 more source

Electrochemical Behavior of Flame‐Sprayed Sc‐Doped AlCoCrFeMo High‐Entropy Alloy Coatings in 3.5% Sodium Chloride Solution

Advanced Engineering Materials, EarlyView.
Scandium (Sc)‐doped AlCoCrFeMo HEA coatings are fabricated via flame spraying with 0.1, 0.3, and 0.5 wt% Sc additions. Among these, the HEA‐Sc0.3 coating exhibits the highest corrosion resistance, indicated by a more positive corrosion potential and lower current density.
Pankaj Kumar, Akash Vyas, Mohammad Aatif Qazi, Nashit Jalal, Maria Ophelia Jarligo, Mostafa Yakout, Jing Liu, André McDonald   +7 more
wiley   +1 more source

Geodesign the multi-layered water safety

Research in Urbanism Series, 2016
This paper aims to frame the multi-layered water safety concept in the context of a systematic, thorough, multidisciplinary and collaborative methodology for complex problems solving, i.e. geodesign. Multi-layered safety is an integrated flood risk management (FRM) concept based not only on flood probability reduction through prevention (layer 1), but ...
Sophronides, Panayiotis, Steenbruggen, John, Scholten, Henk J., Giaoutzi, Maria   +3 more
openaire   +3 more sources