Results 111 to 120 of about 1,674,802 (308)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

How does the WFD address cumulative stress (including mixture toxicity) of pollutants to achieve good chemiscal and ecological status of water bodies?

, 2011
It is now more than ten years ago that the Water Framework Directive (WFD) was adopted by the European Parliament. The main objectives of the WFD are (i) to achieve good ecological and chemical status for inland surface waters, transitional waters and ...
Brock, T.C.M.
core  

Impacts of domestic water supply on gender and income: results from a participatory study in a drought-prone region in Gujarat, India

, 2009
In this paper the value of an improved domestic water supply was investigated for economic development and gender relations in rural households in a drought-prone area.
Nanavaty, Reema, Sijbesma, Christine, Verhagen, Joep, James, A. J.   +3 more
core   +1 more source

“Hurdley technologies” utilized to improve postharvest life of asparagus spears (Asparagus officinalis L.)

Advances in Horticultural Science
Asparagus (Asparagus officinalis L.) has short shelf-life due to the high metabolic activity of the apical meristems. Storage at low temperature and high relative humidity is used commercially to keep fresh asparagus spears.
Martín Ernesto Tiznado-Hernández, Alfonso Antero Gardea-Bejar, Alberto Sánchez-Estrada, Jesús Antonio Orozco-Avitia, Angel Javier Ojeda-Contreras, Rosalba Troncoso-Rojas, Rodrigo Melendrez-Amavizca   +6 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Eleventh Annual Report Water Resources Research Center

, 1975
The fiscal year budget of the Center was $378,584. The Center supported 12 research projects involving 9 faculty members. These research projects were concerned with: developing a water resources research plan for Minnesota; developing indices for ...
Water Resources Research Center
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Bacterial Control of Aquatic Algal Populations [PDF]

, 1977
This study was supported in part by the Office of Water Research and Technology, U. S. Department of the Interior under Project B-051-0HI0(print) iii, 117 leaves, [5] leaves of plates : ill. ; 28 cm.Title Page -- Table of Contents -- Acknowledgements -
Burnham, Jeffrey C.
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Physiological and Biochemical Responses of ‘Burlat’ Sweet Cherry to Pre-Harvest Foliar Application of Calcium and Seaweed Extracts

Horticulturae
Sweet cherry (Prunus avium L.) is a highly valued fruit, and optimal nutrient management is crucial for enhancing yield and fruit quality. However, the over-application of chemical fertilizers in cherry cultivation leads to environmental issues such as ...
Sandra Pereira, Vânia Silva, Francisco Guedes, Fernando Raimundo, João Ricardo Sousa, Ana Paula Silva, Berta Gonçalves   +6 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Water Supply and Sanitation in Niger : Turning Finance into Services for 2015 and Beyond

, 2011
The African Ministers' Council on Water (AMCOW) commissioned the production of a second round of Country Status Overviews (CSOs) to better understands what underpins progress in water supply and sanitation and
World Bank
core   +1 more source