Results 141 to 150 of about 10,149,286 (408)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The impact of water supply variability on treaty cooperation between international bilateral river basin riparian states [PDF]
This paper assesses the impact of water supply variability on treaty cooperation between international bilateral river basin riparian states. Climate change is anticipated to change the variability of water supply, as well as its expected magnitude ...
Blankespoor, Brian +3 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Cutting-Edge Review of Big Data Preprocessing in TBM Tunnel Construction
Shock and VibrationTunnel boring machines (TBMs) accumulate vast operational data crucial for analyzing complex rock-machine interactions during construction. Recent advancements in big data mining and machine learning (ML) have spurred significant artificial intelligence (
Qinghua Guo +5 more
doaj +1 more source
Weightlessness simulation system and process [PDF]
, 1987 A weightlessness simulator has a chamber and a suit in the chamber. O-rings and valves hermetically seal the chamber. A vacuum pump connected to the chamber establishes a pressure in the chamber less than atmospheric pressure.
Vykukal, Hubert C.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Surface water supply of the United States, 1955, Part VI-A, Missouri River basin, Missouri River basin above Sioux City, Iowa [PDF]
, 1957 U.S. Geological Survey
openalex +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Surface water supply of the United States, 1935, Part VI, Missouri River basin [PDF]
, 1936 U.S. Geological Survey
openalex +1 more source