Results 121 to 130 of about 686,576 (312)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Interwater thesaurus for community water supply and sanitation : English version [PDF]
, 1987 Edition: 1stFrench version available in IDRC Digital Library: Interwater thesaurus for community water supply and sanitation : françaisSpanish version available in IDRC Digital Library: Interwater thesaurus for community water supply and sanitation ...
International Reference Centre for Community Water Supply and Sanitation
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Frontiers in Environmental ScienceIntroductionExploring sanitation at a city scale is crucial due to approaches such as Citywide Inclusive Sanitation (CWIS). Sanitation impacts individuals, households and the whole city, as recognised by CWIS.
William Nkonde +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Irrigation and water supply development in Victoria / comp. by Everard Brown. [PDF]
, 1954 new [4th] ed. Electronic reproduction. Canberra, A.C.T.
Victoria. State Rivers and Water Supply Commission.
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Cutting-Edge Review of Big Data Preprocessing in TBM Tunnel Construction
Shock and VibrationTunnel boring machines (TBMs) accumulate vast operational data crucial for analyzing complex rock-machine interactions during construction. Recent advancements in big data mining and machine learning (ML) have spurred significant artificial intelligence (
Qinghua Guo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Feasibility of Utilizing Remote Sources of Water to Augment the Natural Supply of the Tucson Area, Pima County, Arizona: Final Report [PDF]
, 1980 United States Army Corps of Engineers, Los Angeles District, Tucson Urban Study, Eastern Pima County, Regional Water Supply Element / Final Report / The Feasibility of Utilizing Remote Sources of Water to Augment the Natural Supply of the Tucson Area ...
DeCook, K. J. +12 more
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