Results 111 to 120 of about 683,923 (312)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Kansas Public Water Supply Capacity Development Program: Report to the Governor, 2020
, 2020 Water system capacity is the ability to plan for, achieve, and maintain compliance with applicable drinking water standards. Capacity consists of three elements: Technical, Financial, and Managerial (TFM). Technical Capacity or capability is the physical
Kansas. Bureau of Water. Public Water Supply Section
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
GeofluidsThe study used an integrated method of water quality indices (WQIs) and multivariate statistical analysis to evaluate the hydrogeochemical characteristics of groundwater samples and their appropriateness for drinking and agricultural applications in ...
Nurye Mohammed +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Frontiers in Environmental ScienceIntroductionExploring sanitation at a city scale is crucial due to approaches such as Citywide Inclusive Sanitation (CWIS). Sanitation impacts individuals, households and the whole city, as recognised by CWIS.
William Nkonde +4 more
doaj +1 more source
Feasibility Study Report for the Eastern Navarro County Regional Water Supply
, 2014 Study to determine the feasibility of developing a new regional water supply, treatment and transmission system for the Chatfield Water Supply Corporation (CWSC ...
Lockwood, Andrews & Newnam, Inc.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source