Results 111 to 120 of about 2,586,747 (309)
Cutting-Edge Review of Big Data Preprocessing in TBM Tunnel Construction
Shock and VibrationTunnel boring machines (TBMs) accumulate vast operational data crucial for analyzing complex rock-machine interactions during construction. Recent advancements in big data mining and machine learning (ML) have spurred significant artificial intelligence (
Qinghua Guo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
An approach to the economic analysis of water supply projects [PDF]
Development economists are increasingly concerned about the correct approach to economic analysis of projects. By looking for a compromise between theory (which identifies ideals) and practice (which deals within the bounds of time and resource ...
Lovei, Laszlo
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
LRR Focus: Privatizing Lithuania\u27s Water [PDF]
, 1995 [Excerpt] Perhaps nothing is more critical to the maintenance of public health than the supply of clean water. All of the lives saved through modern medicine account for no more than a drop in the bucket when compared to the number of lives saved through
Carbonneau, Marc
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Вестник университетаThe issue of extensive factors in forming and assessing the competitiveness potential of subordinate land reclamation organizations of the Land Reclamation Department of the Ministry of Agriculture of the Russian Federation for working capital has been ...
A. A. Ugryumova +2 more
doaj +1 more source
(2008) Wellhead Protection Program - Lary Lane, Gilman, and Stadium Wells in the Town of Exeter, NH [PDF]
, 2008 A Wellhead Protection Program (WHPP) identifies existing and potential sources of contamination to public water supply wells. The purpose of a WHPP is to prevent contamination of groundwater used for drinking water, recognizing the best way to maintain ...
Wellhead Protection Program
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source