Results 71 to 80 of about 1,114,899 (313)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Experimental Study on Atomizing Performance of Nucleator Nozzle for Outdoor Snow Makers
Zhileng xuebao, 2023 This study investigates the atomizing law of the nucleator nozzles, which are an important atomizing device for domestic outdoor snow-making units. Air and water are used as the medium, and the Sauter mean diameter, atomization flux, and spray angle of ...
Hao Yahui +5 more
doaj +2 more sources
Water Resources ResearchEcosystem moisture availability (ma) increases as the landscape becomes more energy‐limited, driven by either rising water supply or declining energy supply.
Thomas G. Van Niel +5 more
doaj +1 more source
Experimental study of a counter-flow regenerative evaporative cooler [PDF]
, 2016 This paper aims to investigate the operational performance and impact factors of a counter-flow regenerative evaporative cooler (REC). This was undertaken through a dedicated experimental process.
Dong, Xuelin +3 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
PLoS ONE, 2019 Pachycrepoideus vindemmiae is a wasp that parasitizes and host-feeds on pupae of the invasive spotted-wing drosophila (SWD, Drosophila suzukii). Few studies have addressed interactions between these two species and little is known about the potential of ...
Cherre S Bezerra Da Silva +3 more
doaj +1 more source
A novel aspect of essential oils: coating seeds with thyme essential oil induces drought resistance in wheat [PDF]
, 2019 Coating seeds with biostimulants is among the promising approaches in crop production to increase crop tolerance to drought stress. In this study, we evaluated the potential of coating durum wheat seeds of the cultivar ‘Karim’ with thyme essential oil on
Alesami, Noura +9 more
core +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source