Results 91 to 100 of about 1,114,899 (313)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

COMPARATIVE EFFICIENCY OF HEAT-PUMPS APPLICATION IN LOW TEMPERATURE HEAT SUPPLY SYSTEMS

open access: yesИзвестия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2015
The  article  considers  comparative  operation-efficiency  of  the  low-temperature  heatsupply systems with heat pumping plants (HPP) and with hot-water boilers.
M. N. Chepurnoy, N. V. Resident
doaj  

Multiscale evolution of human-water relationship and its influencing factors in the middle and lower reaches of the Yellow River [PDF]

open access: yesZiyuan Kexue
[Objective] This study examined the relationship between humans and water from the perspective of supply and demand, and revealed the complicated relationships between humans and water by exploring the supply-demand relationship of water resources, to ...
RAN Zhao, LIU Yansui, GAO Jianhua
doaj   +1 more source

Thermodynamic analysis of a new ammonia-water power cycle

open access: yesEnergy Reports, 2020
A new ammonia-water power cycle (AWPC) basing on Kalina cycle is presented in this paper, which supply an effective way for low-moderate temperature geothermal power in China.
Bing Hu   +3 more
doaj   +1 more source

Sanitation and Externalities: Evidence from Early Childhood Health in Rural India [PDF]

open access: yes, 2014
This paper estimates two sources of benefits, one direct and the other external, related to sanitation infrastructure access on early childhood health: a direct benefit a household receives when moving from open to fixed-point defecation or from ...
Bertha O   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Nitrogen uptake and the importance of internal nitrogen loading in Lake Balaton [PDF]

open access: yes, 2001
1. The importance of various forms of nitrogen to the nitrogen supply of phytoplankton has been investigated in the mesotrophic eastern and eutrophic western basin of Lake Balaton.<br /> 2.
Herodek, S.   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Stable isotopes in diatom silica [PDF]

open access: yes, 2010
Diatom silica is a form of biogenic opal (SiO2.nH2O, Figure 1) containing oxygen, silicon, carbon and nitrogen isotopes that can be used in lacustrine and marine paleoenvironmental studies.
Leng, Melanie J., Swann, George E.A.
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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