Results 41 to 50 of about 140,050 (252)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Global Assessment of Lake Surface Morphology and Its Impact on Water Volume Estimation

Water Resources Research
Lake surface morphology, an essential yet underexplored feature of hydrological systems, remains poorly understood, including its effects on water volume estimation. This study investigates north‐south surface profiles of 147 lakes worldwide using ICESat‐
Jing Zhang, Dongli Ji, Futian Liu, Hang Ning   +3 more
doaj   +1 more source

Reconstruction of Effective Cross-Sections from DEMs and Water Surface Elevation

Remote Sensing
Knowledge of river bathymetry is crucial for accurately simulating river flows and floodplain inundation. However, field data are scarce, and the depth and shape of the river channels cannot be systematically observed via remote sensing.
Isadora Rezende, Christophe Fatras, Hind Oubanas, Igor Gejadze, Pierre-Olivier Malaterre, Santiago Peña-Luque, Alessio Domeneghetti   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Backwater Effects From River Ice Jams Observed With SWOT Pixel Cloud Data

Geophysical Research Letters
This study examines the backwater effects from ice jams in Arctic rivers using the Surface Water and Ocean Topography (SWOT) satellite. Ice jams occur when chunks of ice accumulate and obstruct the river flow, causing rapid water level rises and flooding.
Linda Christoffersen, Louise Sandberg Sørensen, Ole Baltazar Andersen, Peter Bauer‐Gottwein, Karina Nielsen   +4 more
doaj   +1 more source

Water Level Classification for Detect Flood Disaster Status Using KNN and SVM

Jurnal Sisfokom
Flooding occurs when the water's surface elevation exceeds the average level, overflowing river water and creating inundation in low-lying areas. Early warning for potential floods significantly reduces losses, such as human casualties and property ...
Jiwa Akbar, Muchtar Ali Setyo Yudono
doaj   +1 more source

Airborne observations of arctic-boreal water surface elevations from AirSWOT Ka-Band InSAR and LVIS LiDAR

Environmental Research Letters, 2020
AirSWOT is an experimental airborne Ka-band radar interferometer developed by NASA-JPL as a validation instrument for the forthcoming NASA Surface Water and Ocean Topography (SWOT) satellite mission.
Jessica V Fayne, Laurence C Smith, Lincoln H Pitcher, Ethan D Kyzivat, Sarah W Cooley, Matthew G Cooper, Michael W. Denbina, Albert C. Chen, Curtis W. Chen, Tamlin M. Pavelsky   +9 more
doaj   +1 more source

Tracking River's Pulse From Space: A Global Analysis of River Stage Fluctuations

Geophysical Research Letters, 2023
River stage fluctuation (RSF) is one of the most important factors influencing the physical, chemical, and ecological aspects of rivers. Despite widespread interest in river stage variations, there is currently no global benchmark of RSF and their ...
Yanan Zhao, Liguang Jiang, Xingxing Zhang, Junguo Liu   +3 more
doaj   +1 more source