Results 91 to 100 of about 2,565,844 (218)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Water table reduction shapes soil nematode communities in Zoige peatlands

Global Ecology and Conservation
The water table of the Zoige peatland has been reduced in recent decades due to climate change and human activities. However, as the biological indicators of soil environment, how the response of soil nematode communities to water table reduction was no ...
Zhengchao Yu, Feng Sun, Mei Wang, Na Li
doaj   +1 more source

A Low-Power IoT Device for Measuring Water Table Levels and Soil Moisture to Ease Increased Crop Yields. [PDF]

Sensors (Basel), 2022
López E, Vionnet C, Ferrer-Cid P, Barcelo-Ordinas JM, Garcia-Vidal J, Contini G, Prodolliet J, Maiztegui J.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Düzce Yöresinde Su Kullanımı ve Tabansuyu

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2013
Bu çalışmada, Düzce yöresinde su kullanımı ve tabansuyu durumu irdelenmiştir. Yörede bulanan toplam tarım arazilerinin % 36’sı sulanmakta olup, bu arazilerde ağırlıklı olarak yüzey sulama yöntemi uygulanmaktadır.
Selçuk Özmen
doaj  

Use of graphical and multivariate statistical methods to show a marine intrusion and salinization of a coastal water table: case study of the township of Abomey-Calavi, Benin. [PDF]

Heliyon, 2022
Parfait Hounsinou S.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

SOIL-WATERGRIDS, mapping dynamic changes in soil moisture and depth of water table from 1970 to 2014. [PDF]

Sci Data, 2021
Guglielmo M, Tang FHM, Pasut C, Maggi F.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Author Correction: Deglacial water-table decline in Southern California recorded by noble gas isotopes. [PDF]

Nat Commun, 2021
Seltzer AM, Ng J, Danskin WR, Kulongoski JT, Gannon RS, Stute M, Severinghaus JP.   +6 more
europepmc   +1 more source