Results 121 to 130 of about 2,557,612 (293)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Root temperature and growth of young tomato plants

open access: yes, 1977
During recent years sophisticated techniques are applied in the glasshouse industry for the control of the glasshouse climate. Along with that development, extensive research programs were carried out to establish optimum conditions for growth.
Harssema, H.
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Summary Bulletin: Regulatory Requirements for Controlling Water Temperature in Bathrooms

open access: yes, 2016
This Summary Bulletin relates to the safe provision of heated water in the people’s bathrooms for washing and bathing through the installation of temperature limiting devices.
Carnemolla, P ; https://orcid.org/   +1 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Energy Savings with High Temperature Water Generation Systems

open access: yes, 1982
Since the early 1900's, Europe has been designing and utilizing high temperature water (HTW) systems for process and district heat. The use of HTW systems was chosen over steam systems since HTW offers higher system operating efficiency and lower ...
Manicke, A. C.
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Light-mediated temperature susceptibility of kelp species (Agarum clathratum, Saccharina latissima) in an Arctic summer heatwave scenario

open access: yesCambridge Prisms: Coastal Futures
Kelps (Phaeophyceae, Laminariales) are ecosystem engineers along Arctic rocky shores. With ongoing climate change, the frequency and intensity of marine heatwaves are increasing. Further, extensive meltwater plumes darken Arctic fjords.
Sarina Niedzwiedz   +4 more
doaj   +1 more source

Determination of Pure Neutron Radiolysis Yields for use in Chemical Modeling of Supercritical Water

open access: yes, 2007
This work has determined pure neutron radical yields at elevated temperature and pressure up to supercritical conditions using a reactor core radiation.
Edwards, Eric
core  

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