Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
Evidence of Local Adaptation in a Freshwater Diatom Indicates Higher Sensitivity to Nutrient Limitation as Water Temperature Rises. [PDF]
Ecol EvolZhao L +8 more
europepmc +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Advancing Our Understanding of Surface Water Temperature Dynamics in Transitional Environments through in Situ, Satellite, and Hydrodynamic Modeling. [PDF]
ACS ES T WaterSankara Narayanan NJ +8 more
europepmc +1 more source
Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar +3 more
wiley +1 more source
High male proportions of Nile tilapia in a zero-water exchange biofloc system even at lower methyltestosterone concentration in the feed and water temperature below ideal. [PDF]
Anim ReprodRamírez JFP +15 more
europepmc +1 more source
Ideal water temperature environment for giant Marimo (Aegagropila linnaei) in Lake Akan, Japan. [PDF]
Sci Rep, 2023 Nakayama K +6 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Coupled Effects of Water Temperature and Particle Size on Oxidation Characteristics of Coal: An Experimental Study. [PDF]
ACS OmegaZhang H, Dong Z, Shen M, Yu Y, Zhu P.
europepmc +1 more source
Identifying stream temperature variation by coupling meteorological, hydrological, and water temperature models. [PDF]
J Am Water Resour Assoc, 2023 Tang C, Garcia V.
europepmc +1 more source