Results 91 to 100 of about 21,485,299 (311)
Epidemiological analysis of drinking water-type fluorosis areas and the impact of fluorosis on children's health in the past 40 years in China. [PDF]
Environ Geochem Health, 2023 Wang F +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Study on the Evolution of Water Gushing and Mud Bursting Process in Karst Tunnel
Renmin Zhujiang, 2020 With overall consideration of the influence of geological structure,hydrologic features, andconstruction,this paper abstractly generalizes the evolution of water gushing and mud burstingprocess in karst tunnel into four stages as follows:①The formation ...
LEI Pengbo +5 more
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Systematic review and meta-analysis: Water type and temperature affect environmental DNA decay. [PDF]
Mol Ecol Resour, 2022 Lamb PD +3 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
PRECLINICAL EFFICACY OF A NEWLY IDENTIFIED COMPOUND IN DEPRESSIVE-LIKE PHENOTYPES IN MICE
IBRO Neuroscience Reports, 2023 Carla Ramon-Duaso +5 more
doaj +1 more source
Scientific ReportsTwo Korean strains of Akashiwo sanguinea (LMBE-V203 and LMBE-V287) were established, and their morphologies and molecular phylogenies were examined. In addition, the effects of combined temperature and salinity on their growth and fatty acid contents ...
Ji Yeon Kim +13 more
doaj +1 more source
Renal transcriptome profiles in mice reveal the need for sufficient water intake irrespective of the drinking water type. [PDF]
Sci Rep, 2022 Shon WJ +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source