Results 101 to 110 of about 8,542,420 (355)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Simulating Root Density Dynamics and Nitrogen Uptake -Field Trials and Root Model Approach in Denmark [PDF]

, 2007
Plant soil and atmosphere models are commonly used to predict crop yield and associated environmental consequences. Such models often include complex modelling of water movement, soil organic matter turnover and above ground plant growth.
Jensen, Lars Stoumann, Pedersen, Anders, Thorup-Kristensen, Kristian, Zhang, Kefeng   +3 more
core  

A "water shell" model for the dielectric properties of hydrated silica-filled epoxy nano-composites [PDF]

, 2007
The electrical properties of epoxy resin have been studied as a function of hydration. The epoxy was studied in an un-filled state, filled with 40 µm SiO2 particles, and filled with 50 nm SiO2 particles.
Fothergill, J., Rowe, S. W., Zou, C.
core   +1 more source

Ion uptake in naturally acidic water

Journal of Comparative Physiology B
AbstractThe first studies on ion regulation in fish exposed to low pH, which were inspired by the Acid Rain environmental crisis, seemed to indicate that ion transport at the gills was completely and irreversibly inhibited at pH 4.0–4.5 and below. However, work on characid fish native to the Rio Negro, a naturally acidic, blackwater tributary of the ...
Gonzalez, R. J., Patrick, M. L., Val, A. L.   +2 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Proximate controls on semiarid soil greenhouse gas fluxes across 3 million years of soil development [PDF]

, 2015
Soils are important sources and sinks of three greenhouse gases (GHGs): carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O). However, it is unknown whether semiarid landscapes are important contributors to global fluxes of these gases, partly ...
Hart, SC, Hungate, BA, Nasto, MK, Sullivan, BW   +3 more
core   +1 more source

Water absorption and degradation characteristics of chitosan-based polyesters and hydroxyapatite composites [PDF]

, 2007
Blends of chitosan and biodegradable synthetic aliphatic polyesters (polycaprolactone, poly-(butylene succinate), poly[(butylene succinate)-co-adipate], poly[(butylene terephthalate)-co-adipate], and poly(lactic acid)) were injection-molded.
Alberta Araújo, Asaoka, Azevedo, Berens, Chan, Chapman, Correlo, Correlo, Crank, Demirgöz, Han, Jamshidi, Joshi, Khang, Koyano, Lu, Lydon, Mani, McCall, Nogueira, Ramkumar, Ratner, Reis, Santerre, Santos, Sashiwa, Schamberger, Scotchford, Sideridou, Suarez, Sun, Toselli, Valles, Vaz, Vrentas, Vrentas, Wang, Wu   +37 more
core   +1 more source

On-farm adoption of irrigation technologies in two irrigated valleys in Central Chile : the effect of relative abundance of water resources [PDF]

, 2020
This paper examines the adoption of irrigation technologies and the underlying diversity in terms of intensity of adoption in 2 irrigated valleys in Central Chile.
Jordán Díaz, Cristian, Speelman, Stijn
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source