Results 131 to 140 of about 3,375,307 (312)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Revealing the impact of socio-demographic factors and efficient devices on end use water consumption: case of Gold Coast, Australia

, 2009
Comprehension of the differences in water consumption within communities and the actual water savings attributed to engineered efficient devices requires high accuracy data generally of the end use water consumption form.
Willis, Rachelle, Stewart, Rodney, Mousavinejad, Alireza, Jones, Sarah, Talebpour, Reza, Giurco, Damien   +5 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Basin-Wide Water Budgeting Using an Integrated Model

, 2007
Proceedings of the 2007 Georgia Water Resources Conference, March 27-29, 2007, Athens, Georgia.Integrated surface water/groundwater models have been used extensively for water budgeting and water resource allocation projects in Florida.
deGolian, Peter, Dabbs, Clyde, Yang, Jing Yea   +2 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Integrated Assessment of Metal Contamination of Soils, Sediments, and Runoff Water in a Dry Riverbed from a Mining Area Under Torrential Rain Events

Land
Dry riverbeds can transport mining waste during torrential rain events, disseminating pollutants from mining areas to natural ecosystems. This study evaluates the impact of these mine wastes on soils, sediments, and runoff/pore water in the La ...
José Cuevas, Ángel Faz, Silvia Martínez-Martínez, Juan Beltrá, José A. Acosta   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Multifunctional Greenway Approach for Landscape Planning and Reclamation of a Post-Mining District: Cartagena-La Unión, SE Spain

Land
Establishing a sustainable framework for remediating environmental degradation caused by historical mining operations in the Sierra Minera of Cartagena-La Unión, southeastern Spain, is a critical imperative.
Angel Faz, Sebla Kabas, Raul Zornoza, Silvia Martínez-Martínez, Jose A. Acosta   +4 more
doaj   +1 more source

Incidental Recharge in the Lower Flint River Basin: Agricultural Irrigation and Consumptive Use

, 2007
Proceedings of the 2007 Georgia Water Resources Conference, March 27-29, 2007, Athens, Georgia.The purpose of this study is to develop a method for estimating the irrigation consumptive use of water in the Lower Flint River Basin.
Masters, Mark H., Sakura-Lemessy, Donna-May   +1 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source