Results 101 to 110 of about 892,459 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Optimizing the Water and Nitrogen Management Scheme to Enhance Potato Yield and Water–Nitrogen Use Efficiency

Water and nitrogen are the primary constraints on improving agricultural productivity. The aims of this study are to investigate the synergistic effects of water and nitrogen, optimize their combination schemes under mulched drip irrigation systems in ...
Zhiqiang Ju, Dongyuan Sun, Dongrong Li, Yanqiang Cui   +3 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Effects of Different Irrigation Methods on Environmental Factors, Rice Production, and Water Use Efficiency

, 2020
Rice is one of the most important food crops in China and is also the largest user of agricultural water. Experiments were conducted for two consecutive years at two locations of Jiangsu province to study the effect of four irrigation methods with four ...
Liang Sen, Xiangping Guo, Ghulam Rasool, Kewen Cao, Shuxuan Zhang   +4 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Soil water dynamics and water use efficiency in spring maize (Zea mays L.) fields subjected to different water management practices on the Loess Plateau, China

, 2010
Soil water supply is the main limiting factor to crop production across the Loess Plateau, China. A 2-year field experiment was conducted at the Changwu agro-ecosystem research station to evaluate various water management practices for achieving ...
Li, SQ, Liu Yi, Chen Fang, Li Shiqing
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Biomass allocation, relative competitive ability and water use efficiency of two dominant species in semiarid Loess Plateau under water stress

, 2011
A better understanding of the growth and interspecific competition of native dominant species under water stress should aid in prediction of succession in plant communities. In addition, such research would guide the selection of appropriate conservation
Xu Wei-Zhou, Huang Jin, Xu, BC, Xu Bing-Cheng   +3 more
core  

Bacillus aryabhattai Improves Agronomic Performance and Water Use Efficiency of Common Bean Under Deficit Irrigation Levels

Crops
The common bean (Phaseolus vulgaris L.) is of great food and economic importance in Brazil, but its productivity is highly affected by water deficit due to its superficial root system and short cycle.
Ana L. P. Oliveira, João P. Santos, Gustavo F. Silva, Fernando F. Putti   +3 more
doaj   +1 more source