Results 61 to 70 of about 767,368 (266)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Irrigation and Fertigation Scheduling under Drip Irrigation in Brinjal (Solanum melongena L.) Crop

International Journal of Bio-Resource and Stress Management, 2010
Field experiments were conducted (Field No. NC-17) at Agricultural Research Station, Bhavanisagar during 2007 and 2008 to maximize the water and fertilizer use efficiency in brinjal crop.
G. Vijayakumar, D. Tamilmani, P. K. Selvaraj   +2 more
doaj  

Water use efficiency data from 2000 to 2019 in measuring progress towards SDGs in Central Asia

Big Earth Data, 2020
Central Asia, located in the hinterland of the Eurasian continent, is characterized with sparse rainfall, frequent droughts and low water use efficiency.
Yaning Chen, Gonghuan Fang, Haichao Hao, Xuanxuan Wang   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Impact of Planting Windows on Growth, Yield and Economics of Potato Production under Climate Change Scenario in Central India

International Journal of Bio-Resource and Stress Management, 2016
A field experiment was conducted to study adaptation of potato to climate aberrations at Central Potato Research Station, Gwalior, India which is located in Central Plains of India.
S. P. Singh
doaj  

Sustaining Water Resources: A Study on Conservation Efforts in Taman Merlimau Bestari

Jurnal Civil Engineering Study
This study examines water use efficiency in the residential area of Taman Merlimau Bestari, Melaka, in response to the threat of water shortages exacerbated by extreme hot weather.
Hassan Ismail
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Concepts d'efficience et de productivité de l'eau (synthèse bibliographique)

Biotechnologie, Agronomie, Société et Environnement, 2014
Water efficiency and productivity concepts. A review. Water efficiency and productivity indicators are used in many scientific disciplines, usually to account for water losses that occur during its use, or products generated per unit of water consumed ...
Kambou, D., Xanthoulis, D., Ouattara, K., Degré, A.   +3 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source