Results 41 to 50 of about 42,729 (260)

Comprehensive effects of interdecadal change of sea surface temperature increase in the Indo-Pacific Ocean on the warming-wetting of the Qinghai–Tibet Plateau

Scientific Reports, 2022
The correlation characteristics between anomalous changes in summer precipitation on the Qinghai–Tibet Plateau (QTP) and the high-impact areas of global sea-surface temperature (SST) are mainly studied in this paper.
Na Dong, Xiangde Xu, Wenyue Cai, Tianliang Zhao, Chan Sun   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Novel ultrasonic dynamic vapor sorption apparatus for adsorption drying, cooling and desalination applications

Energy Reports, 2022
Adsorption systems for desalination, drying, and cooling applications could be powered by renewable energy sources. Thus, it is a promising technology for solving energy and water problems.
Ehab S. Ali, Ramy H. Mohammed, A.E. Zohir, A.M. Farid, Ramadan N. Elshaer, Hamdy H. El-Ghetany, Ahmed A. Askalany   +6 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Water vapor sources and their contributions to precipitation change in the Tibetan Plateau

Shui kexue jinzhan
In recent decades，precipitation on the Tibetan Plateau（TP）increased in the north and decreased in the south，leading to greater complexity and uncertainty of the water resources system.
Lijuan YE, Wen WANG, Yanjun HU, Zengxin ZHANG, Yucheng LI   +4 more
doaj   +1 more source

Surface and Tropospheric Water Vapor Variability and Decadal Trends at Two Supersites of CO-PDD (Cézeaux and Puy de Dôme) in Central France

Atmosphere, 2018
We present an analysis of decadal in situ and remote sensing observations of water vapor over the Cézeaux and puy de Dôme, located in central France (45° N, 3° E), in order to document the variability, cycles and trends of surface ...
Dani Hadad, Jean-Luc Baray, Nadège Montoux, Joël Van Baelen, Patrick Fréville, Jean-Marc Pichon, Pierre Bosser, Michel Ramonet, Camille Yver Kwok, Nelson Bègue, Valentin Duflot   +10 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Analysis of water vapor transport characteristics of a monsoon low-pressure continuous heavy rain event at the end of August 2018 in Guangdong area

暴雨灾害, 2019
Based on the NCEP reanalysis, conventional observation and Global Data Assimilation System (GDAS) data, the characteristics of water vapor transport were analyzed in a historically extreme event of persistent heavy rainstorm affected by a monsoon low ...
Ziyou GUO, Zhifang WU, Jingjiu CAI, Hualong ZHANG, Xiaoyang CHEN   +4 more
doaj   +1 more source