Results 51 to 60 of about 55,043 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Interannual Variability in the Meridional Transport of Water Vapor

Journal of Hydrometeorology, 2000
The zonal-mean meridional transport of water vapor across the globe is evaluated using the National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) reanalysis for 1948-97. The shape of the meridional profile of the climatological mean transport closely resembles that of previous mean climate descriptions, but ...
Judah L. Cohen, David A. Salstein, Richard D. Rosen   +2 more
openaire   +1 more source

Changes in water vapor transports of the ascending branch of the tropical circulation [PDF]

Journal of Geophysical Research, 2011
Recent studies have found contradicting results on whether tropical atmospheric circulation (TAC) has intensified or weakened in recent decades. We here re-investigate recent changes in TAC derived from moisture transports into the tropics using high temporal and spatial resolution reanalyses from ERA-interim.\ud We found a significant strengthening of
Zahn, Matthias, Allan, Richard
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Intercomparison of Water Vapor Data Measured with Lidar during IHOP_2002. Part II: Airborne-to-Airborne Systems

, 2007
The dataset of the International H2O Project (IHOP_2002) gives the first opportunity for direct intercomparisons of airborne water vapor lidar systems and allows very important conclusions to be drawn for future field campaigns.
Wulfmeyer, Volker, Ferrare, Richard, Ismail, Syed, Schaberl, Thorsten, Andreas Behrendt, Richard Ferrare, Whiteman, David N., Kooi, Susan, Ehret, Gerhard, Browell, Edward V., Kiemle, Christoph, Volker Wulfmeyer, Behrendt, Andreas, Christoph Kiemle, N. Whiteman, David, Gerhard Ehret, Syed Ismail, Flamant, Cyrille, Cyrille Flamant, Bauer, Hans-Stefan, Susan Kooi, Browell, E.-V., David N. Whiteman, Thorsten Schaberl, Edward V. Browell, Hans-Stefan Bauer   +25 more
core   +1 more source

Can Water Vapor Transport over the Himalayas above 8000 m asl?—A Case Study on Mt. Everest

, 2022
Due to the extreme, harsh natural environment in the Himalayas higher than 8000 m above sea level (asl) long-term and continuous meteorological observation is still a great challenge, and little is known about water vapor transport in this extremely high
Bing Xu, Aihong Xie, Jiangping Zhu
core   +1 more source

Modulation of sea surface temperature in three oceans on precipitation increase over Northwest China during the past 60 years: A review

Frontiers in Climate, 2022
Northwest China is a typical arid and semi-arid region that is part of Central Asia. However, during the past 60 years, the climate in Northwest China has shown a warm and humid trend, with both average and extreme precipitation continuing to increase ...
Yihui Ding, Ping Wu, Yanju Liu
doaj   +1 more source

Segmented shape memory polyurethane and its water vapor transport properties [PDF]

Designed Monomers and Polymers, 2006
An attempt has been made to review the influences of different structural factors on physical and water vapor transport properties of segmented shape memory polyurethane (SPU) for breathable textile, biomedical and many other industrial applications. The differences between ordinary, segmented and segmented shape memory polyurethanes have been reviewed.
Mondal, S., Hu, J. L.
openaire   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Horizontal structure function and vertical correlation analysis of mesoscale water vapor variability observed by airborne lidar

, 2013
Analysis is presented of airborne lidar measurements of water vapor, covering a height range from 1.5 to 10.4 km, from three field campaigns (midlatitude summer, polar winter, and subtropical summer).
Kiemle, Christoph, L. Fischer, Fischer, Lucas, C. Kiemle, Craig, George C., G. C. Craig   +5 more
core   +1 more source