Results 101 to 110 of about 820,733 (267)

Revegetation Reduces Soil Moisture and Groundwater but Not Water Yield in Humid Karst Areas

Water Resources Research
While vegetation restoration results in increased carbon storage and benefits ecosystems, its effects on water availability in ecologically fragile karst areas are unclear.
Sibo Zeng, Yongjun Jiang, Zaihua Liu, Junbing Pu, Kazakis Nerantzis, Qiufang He, Ze Wu, Xing Tian   +7 more
doaj   +1 more source

Research Progress on Identification of Basin Water Yield Baseline and Regulation Slope Water Yield Process

Polish Journal of Environmental Studies
Due to the influence of climate change and human activities, slope water yield characteristics have changed, and the “activity” of water has begun to weaken, resulting in slope ecological degradation and river runoff attenuation. To carry out refined water system management and delay environmental degradation in the basin, it is necessary to accurately
Wenyu Wang, Jun Hou, Xin Zhang, Tao Du, Shizhi Wang, Tianling Qin   +5 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Projecting Water Yield Amidst Rapid Urbanization: A Case Study of the Taihu Lake Basin

Land
Changes in land cover and land use (LULC) can impact water availability by altering the structure and functioning of land ecosystems. Accurately projecting the impacts of LULC on water yield (WY) is of utmost importance for regional landscape management.
Rui Zhou, Yanan Zhou, Weiwei Zhu, Li Feng, Lumeng Liu   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Assessing Climate Change Impacts on Yield of “Dual‐Priority” Water Rights in Carryover Systems at Catchment Scale

Water Resources Research
Future water availability is threatened by changes in both climate and water demand. Water rights with differing priorities are an important foundation of demand‐side tools (e.g., buyback, water pricing, and water market) to improve water use efficiency ...
Peizhen Ren, Michael Stewardson, Murray Peel, Margot Turner, Andrew John   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Effects of Landscape Pattern Change on Water Yield and Nonpoint Source Pollution in the Hun-Taizi River Watershed, China. [PDF]

Int J Environ Res Public Health, 2020
Zong M, Hu Y, Liu M, Li C, Wang C, Ping X.   +5 more
europepmc   +1 more source