Results 81 to 90 of about 820,733 (267)

Spatiotemporal Patterns and Nonlinear Drivers of Water Yield in Inner Mongolia

open access: yesHydrology
Water yield is a key indicator for regional water resource assessment and directly concerns multidimensional socio-ecological sustainability. However, in arid and semi-arid regions, integrated long-term water yield simulation and nonlinear interpretation
Cairui Fan   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Unveiling the Synergies and Conflicts Between Vegetation Dynamic and Water Resources in China’s Yellow River Basin

open access: yesLand
Understanding the relationship between regional vegetation dynamics and water resources is essential for improving integrated vegetation–water management, enhancing ecosystem services, and advancing the sustainable development of ecological–economic ...
Zuqiao Gao, Xiaolei Ju
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Direct and Indirect Effects of Large-Scale Forest Restoration on Water Yield in China’s Large River Basins

open access: yesRemote Sensing
Emerging evidence indicates that large-scale forest restoration exhibits dual hydrological effects: direct reduction of local water availability through elevated evapotranspiration (ET) and indirect augmentation of water resources via enhanced ...
Yaoqi Zhang, Lu Hao
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Integrated assessment of land use/land cover changes and hydrological impacts in the nile river basin: a case study of Rwanda hydro-unity network

open access: yesFrontiers in Environmental Science
This study evaluates the impacts of land use and land cover (LULC) changes on streamflow dynamics and water availability within the Rwanda Hydro-Unity Network catchment, part of the Nile River basin.
Egide Hakorimana   +43 more
doaj   +1 more source

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