Results 51 to 60 of about 151,723 (291)

Blockchain-based Decentralized Distribution Management in E-Journals [PDF]

open access: yes, 2020
The application of blockchain in the context of E-Journal distribution to journalists is aimed at making the management paper adequately distributed and not misused.
Agustin, F. (Farida)   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Direct Connection between Mott Insulator and d-Wave High-Temperature Superconductor Revealed by Continuous Evolution of Self-Energy Poles

open access: yes, 2018
The high-temperature superconductivity in copper oxides emerges when carriers are doped into the parent Mott insulator. This well-established fact has, however, eluded a microscopic explanation.
Civelli, Marcello   +2 more
core   +3 more sources

Historical roots of Agile methods: where did “Agile thinking” come from? [PDF]

open access: yes, 2008
The appearance of Agile methods has been the most noticeable change to software process thinking in the last fifteen years [16], but in fact many of the “Agile ideas” have been around since 70’s or even before.
A. Cockburn   +22 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Specific Management of IT-Projects

open access: yesВестник Российского экономического университета имени Г. В. Плеханова, 2023
Projects act as an important tool of corporate governance as it is possible to attain with their help strategic organizational goals. Significance of efficient project management is recognized by companies all over the world, as not always it is possible
Y. V. Lyandau, A. S. Butkevich
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Sistem Manajemen Proyek Berbasis Website Dengan Metode Kanban

open access: yesComputer Science
The advancement of digital technology has created a growing demand for systems that support work effectiveness, particularly in project management. The Digital Learning Division at PT.
Florence Aurelia Widjaja, Bhustomy Hakim
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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