Results 61 to 70 of about 151,723 (291)

Perancangan Media Digital Dalam Revitalisasi Panduan Haji Mandiri Di Era 4.0

open access: yesJurnal Informatika dan Rekayasa Perangkat Lunak, 2021
Dalam era globalisasi, teknologi informasi berkembang sangat pesat yang meranah pada seluruh aspek kehidupan mulai dari instansi pendidikan, perusahaan, pemerintahan, bahkan kehidupan sehari-hari.
Mustagfirin Mustagfirin   +2 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Massive Primordial Black Holes from Hybrid Inflation as Dark Matter and the seeds of Galaxies [PDF]

open access: yes, 2015
In this paper we present a new scenario where massive Primordial Black Holes (PBH) are produced from the collapse of large curvature perturbations generated during a mild waterfall phase of hybrid inflation.
Clesse, Sébastien   +1 more
core   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Dynamic behavior analysis for a six axis industrial machining robot [PDF]

open access: yes, 2012
The six axis robots are widely used in automotive industry for their good repeatability (as defined in the ISO92983) (painting, welding, mastic deposition, handling etc.).
Bisu, Claudiu-Florinel   +3 more
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Constructive waterfalls [PDF]

open access: yesScottish Geographical Magazine, 1911
The excavation of valleys by waterfalls is one of the best known and most effective processes by which rivers cut down the surface of the earth. The influence of waterfalls is usually regarded as solely destructive, and as always helping to lower the land.
openaire   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Origin of the "Waterfall" Effect in Phonon Dispersion of Relaxor Perovskites [PDF]

open access: yes, 2003
Inelastic neutron scattering study of the perovskite relaxor ferroelectric PZN:8%PT elucidates the origin of the previously reported unusual kink on the low frequency transverse phonon dispersion curve (known as "waterfall" effect).
Hlinka, J.   +5 more
core   +2 more sources

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