Results 111 to 120 of about 236,702 (302)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Across the Watershed, Spring 2007
, 2007 This is the quarterly publication of the Great Swamp Watershed Association (GSWA), a nonprofit watershed association working to protect the ecological, historic, and cultural integrity of the Great Swamp and its watershed.
core +1 more source
Mécanismes et maitrise de la pollution diffuse agricole : le cas du phosphore et sa portée générale
Biotechnologie, Agronomie, Société et Environnement, 2013 Mechanisms and control of agricultural diffuse pollution: the case of phosphorus. The movement of phosphorus is primarily a surface phenomenon closely related to surface runoff and erosion.
Dorioz, JM.
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
GeosciencesSoils have an important task in maintaining vegetation cover and natural resources on Earth and are indispensable to societies. However, the accelerated soil erosion has become an environmental problem related to land settlement for agricultural ...
Wellynne Carla de Sousa Barbosa +2 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Across the Watershed, Fall-Winter 2009
, 2009 This is the quarterly publication of the Great Swamp Watershed Association (GSWA), a nonprofit watershed association working to protect the ecological, historic, and cultural integrity of the Great Swamp and its watershed.
core +1 more source
AgricultureAnthropogenic nitrogen (N) inputs can have detrimental environmental effects, necessitating a comprehensive understanding of the nitrogen budget (NB) and its spatial correlation with the water quality.
Deok-Woo Kim +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source