Results 51 to 60 of about 6,871,602 (345)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Maximum Stress Analysis on Ship Anchor Chains with Various Force Angles

Wave
One of the components of ship fittings is the anchor chain. Usually, when the anchor is moored, it is not always positioned perpendicular to the ship’s hull; instead, it often forms an angle between the chain and the hull. Due to environmental influences
Chris Jeremy Verian Sitorus, Luluh Wardah, Alamsyah, Suardi, Andi Mursid Nugraha Arifuddin, Samsu Dlukha Nurcholik, Hariyono, Jusma Wahidah, Harlian Kustiwansa, Ahmad Azwar Mas`ud M   +9 more
doaj   +1 more source

ANALISA PENGARUH KOMPONEN KUADRATIK DAMPING PADA DECAY TEST BUOY TSUNAMI 3.1

Wave, 2021
Koefisien damping sangat berperan dalam akurasi prediksi gerak suatu benda apung. Dari pengujian decay akan didapatkan komponen koefisien damping linear a dan kuadratik b.
Baharuddin Ali, Totok Triputrastyo Murwantono, Sumarsono Sumarsono, Chandra Permana   +3 more
doaj  

Wave Solutions

, 2012
In classical continuum physics, a wave is a mechanical disturbance. Whether the disturbance is stationary or traveling and whether it is caused by the motion of atoms and molecules or the vibration of a lattice structure, a wave can be understood as a ...
Christov, Ivan C.
core   +1 more source

Run-up characterstics of symmetrical solitary tsunami waves of unknown shapes [PDF]

, 2008
The problem of tsunami wave run-up on a beach is discussed in the framework of the rigorous solutions of the nonlinear shallow-water theory. We present an analysis of the run-up characteristics for various shapes of the incoming symmetrical solitary ...
Didenkulova, Ira, Pelinovsky, Efim, Soomere, Tarmo   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Primordial black holes—perspectives in gravitational wave astronomy [PDF]

, 2018
This article reviews current understanding of primordial black holes (PBHs), with particular focus on those massive examples (≳1015 g) which remain at the present epoch, not having evaporated through Hawking radiation. With the detection of gravitational
M. Sasaki, T. Suyama, Takahiro Tanaka, Shuichiro Yokoyama   +3 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A Modular Tide LevePrediction Using Combination Ofharmonic-Analysis and Nonlinear Autoregressive Exogenous (Narx) Methodology in Semarang Indonesia

Wave
Semarang is highly prone to tidal floods year-round, making tidal prediction using methods like Harmonic Analysis with Least Squares (HA-LS) crucial for disaster mitigation. However, this method is not effective enough because it has relatively high Root
Elvien Hastatomo Khasby, Anistia Malinda Hidayat, Usman Efendi, Pulung Nurtantio Andono, Catur Supriyanto, Arief Soeleman, Ferry Oktarisa, Aurel Dwiyana   +7 more
doaj   +1 more source

STUDI INTERAKSI KAPAL - PROPELER PADA PLANING HULL AKIBAT PERBEDAAN SUDUT DEADRISE

Wave, 2022
Pemilihan sudut deadrise pada planing hull dan pengaruh pada kurva beban propeler dilakukan untuk memberikan gambaran yang jelas terhadap pemilihan mesin utama dan kecepatan kapal.
Erifive Pranatal, R. Puranggo Ganjar Widityo, Fitria Fresty Lungari   +2 more
doaj