Results 41 to 50 of about 1,274,094 (294)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Coupled Vibration Analysis of Submerged Floating Tunnel System in Wave and Current

Applied Sciences, 2018
Submerged floating tunnel (SFT) is an innovative underwater structure for crossing long straits, which withstands the effects of water wave and current throughout its lifecycle.
Zhengyang Chen, Yiqiang Xiang, Heng Lin, Ying Yang   +3 more
doaj   +1 more source

Observing the phase space trajectory of an entangled matter wave packet

, 2010
We observe the phase space trajectory of an entangled wave packet of a trapped ion with high precision. The application of a spin dependent light force on a superposition of spin states allows for coherent splitting of the matter wave packet such that ...
Poschinger, Ulrich, Schmidt-Kaler, Ferdinand, Singer, Kilian, Walther, Andreas   +3 more
core   +1 more source

WAVE FORCES ON PIPELINES

Coastal Engineering Proceedings, 1974
Water waves exert a force on a pipeline which is placed within the zone of wave influence. This force is made up of a periodic force which is composed of a drag and an inertial force, and a non-periodic second order force which acts upward. The coefficients of mass C and drag C as defined by the "Morison equation" were evaluated for many wave and depth
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Modeling Hurricane Wave Forces Acting on Coastal Bridges by Artificial Neural Networks

Journal of Marine Science and Engineering
Artificial neural networks have been evaluated and compared for modeling extreme wave forces exerted on coastal bridges during hurricanes. Long Short-Term Memory (LSTM) is selected for deep learning neural networks. A feedforward neural network (FFNN) is
Hong Xiao, Wenrui Huang, Jiahui Wang
doaj   +1 more source

Casimir force on interacting Bose-Einstein condensate

, 2010
We have presented an analytic theory for the Casimir force on a Bose-Einstein condensate (BEC) which is confined between two parallel plates. We have considered Dirichlet boundary conditions for the condensate wave function as well as for the phonon ...
Annett J F, Bhattacharyya S, Biswas S, Biswas S Bhattacharjee J K Samanta H S Bhattacharyya S Hu B, Brevik I, Buenzli P R, Casimir H B G, Dwipesh Majumder, Edery A, Edery A, Gambassi A, Hasenbusch M, J K Bhattacharjee, Jancovici B, Kush Saha, Lambrecht A, Lifshitz E M, Maciolek A, Martin P A, Nabajit Chakravarty, Pitaevskii L, Roberts D C Pomeau Y, Schiefele J, Shyamal Biswas, Yu X L   +24 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Three-dimensional numerical simulation of wave interaction with perforated quasi-ellipse caisson

Water Science and Engineering, 2011
The finite difference method and the volume of fluid (VOF) method were used to develop a three-dimensional numerical model to study wave interaction with a perforated caisson.
Yong-xue Wang, Xiao-zhong Ren, Ping Dong, Guo-yu Wang   +3 more
doaj   +1 more source