Results 51 to 60 of about 13,536 (264)
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
We show that there are Hilbert spaces constructed from the Hausdorff measures \mathcal{H}^{s} on the real line \mathbb{R} with
Dorin E. Dutkay, Palle E.T. Jorgensen
openaire +5 more sources
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
On the regularity of wavelets [PDF]
Summary: The regularity index \(\alpha_ N\) of the scaling functions \(_ N\phi\), \(N=2,3,\dots\), of multiresolution analysis introduced by \textit{I. Daubechies} [Commun. Pure Appl. Math. 41, No. 7, 901-996 (1988; Zbl 0644.42026)] is investigated.
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Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Variation-Diminishing Wavelets and Wavelet Transforms
By using Schoenberg's theory of convolution transform variation, diminishing wavelets and wavelets of specific changes in sign are constructed. An inversion formula involving derivatives of the wavelet transform is also established. Wavelets generated by Tanno's form of convolution kernels and H-functions are also investigated.
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Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chang, Ee-Chien +2 more
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ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
WAVELETS AND WAVELET FRAMES ON THE 2-SPHERE
We review the construction of the continuous wavelet transform (CWT) on the 2-sphere by two methods, the group-theoretical approach and the geometrical method based on conformal invariance. Then we discuss the discretization of the spherical CWT and build associated discrete wavelet frames, first half-continuous ones (only the scale is discretized ...
openaire +2 more sources

