Results 51 to 60 of about 128,242 (264)

Nuclear Morphology Measurements with Angle-Resolved Low Coherence Interferometry For Application To Cell Biology And Early Cancer Detection

open access: yesAnalytical Cellular Pathology, 2011
The study of intact, living cells using non-invasive optical spectroscopic methods offers the opportunity to assess cellular structure and organization in a way that is not possible with commonly used cell biology imaging techniques.
Adam Wax, Kevin J. Chalut
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Compositional data on sunflower seed grown in Argentine

open access: yesGrasas y Aceites, 1993
Constituents seed oil content, physic structure, oil seed quality and wax content are evaluated. The relations of these characters and its agroclimatic interactions facilitate the introduction of this cultivar into food and/or industrial market ...
E. Santalla, I. Riccobene, S. Nolasco
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Waxes used as structuring agents for food organogels: A Review

open access: yesGrasas y Aceites, 2020
Lipids are key ingredients in the human diet. Because of the manipulation and modification of lipids in the food industry, the amount of trans and saturated fat has been substantially increasing in industrialized products. At the same time, the number of
C. C. Mandu   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Theoretical investigation of the effects of wax content on the functioning of bitumen and asphalt pavement

open access: yesMokslas: Lietuvos Ateitis, 2020
This paper reviews effect of wax content to performance of bitumen and asphalt pavement. Negative influence of wax content is known from literature reviews, which effects elasticity of binder and causes sensitivity to low temperatures and increases ...
Simona Bitarytė, Audrius Vaitkus
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

APLICACIÓN DE UN TRATAMIENTO QUÍMICO PARA EL CONTROL DE PARAFINAS EN LA TUBERÍA DE PRODUCCIÓN EN EL CRUDO DEL CAMPO ESCUELA COLORADO

open access: yesRevista Fuentes El Reventón Energético, 2019
This paper presents the implementation of a chemical treatment in a pilot well of the Colorado Field to prevent the precipitation and deposition of paraffins in the production tubing.
Crisóstomo Barajas Ferreira   +3 more
doaj  

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