Results 101 to 110 of about 1,252,422 (303)
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Etnički i politički identitet predmodernog Dubrovnika od 14. do 17. stoljeća
Anali Zavoda za Povijesne Znanosti Hrvatske Akademije Znanosti i Umjetnosti u Dubrovniku, 2017 This article investigates the ways in which premodern Ragusans understood the relationship between two types of collective identity: their civic identity, the belonging to the community of the Ragusan city-state, and their ethnic identity, the belonging ...
Lovro Kunčević
doaj +1 more source
Students’ personality impacts sense of belonging of students in different ways
Social Psychology of EducationAbstract The sense of belonging satisfies the need for relatedness which is one of the three basic psychological needs. It is considered to be a foundation for success in higher education. One of the predictors of sense of belonging from a psychological perspective is students’ personality in the sense of Big Five traits.
Carla Bohndick +3 more
openaire +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source
Talking about boundaries: Symbolic boundaries and ethno-racial repertoires in contemporary Brazil.
French Journal for Media Research, 2018 The article argues that there is a shift in core conceptions of identity and belonging in Brazil’s national identity narrative. Analysing the discourse on affirmative action in favour of black people in contemporary Brazil, we discuss three ...
Oliveira Nuno
doaj
Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki +8 more
wiley +1 more source
Who Gets to Belong in Chemistry? A Decolonization Perspective Informed by Dominant Group Theory
Education SciencesA sense of belonging in science, technology, engineering, and mathematics (STEM) education is often conceptualized primarily through social dimensions, overlooking its disciplinary and epistemological contexts.
Zakiya S. Wilson-Kennedy +2 more
doaj +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source