Results 61 to 70 of about 11,022 (263)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Existence of a mountain pass solution for a nonlocal fractional ( p , q ) $(p, q)$ -Laplacian problem

Boundary Value Problems, 2020
Here, a nonlocal nonlinear operator known as the fractional ( p , q ) $(p,q)$ -Laplacian is considered. The existence of a mountain pass solution is proved via critical point theory and variational methods.
F. Behboudi, A. Razani, M. Oveisiha
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

On a Fractional Nonlinear Hyperbolic Equation Arising from Relative Theory

Abstract and Applied Analysis, 2013
We obtain the existence of a weak solution to a fractional nonlinear hyperbolic equation arising from relative theory by the Galerkin method. Its uniqueness is also discussed. Furthermore, we show the regularity of the obtained solution. In our proof, we
Zujin Zhang, Xiaofeng Wang, Zheng-an Yao
doaj   +1 more source

Multiplicity of solutions for quasilinear elliptic problems involving $\Phi$-Laplacian operator and critical growth

Electronic Journal of Qualitative Theory of Differential Equations, 2019
In this paper, we study a class of quasilinear elliptic equations with $\Phi$-Laplacian operator and critical growth. Using the symmetric mountain pass theorem and the concentration-compactness principle, we demonstrate that there exists $\lambda_i>0 ...
Xuewei Li, Gao Jia
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Weak Compactness in Spaces of Differentiable Mappings

Rocky Mountain Journal of Mathematics, 1995
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
González, Manuel, Gutiérrez, Joaquín M.   +1 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Structural Aspects of Weak Connectedness and Weak Compactness in Bipolar Soft Weak Structures

Transactions on Fuzzy Sets and Systems
Connectedness and compactness are two essential properties that characterize the structural behavior of topological spaces. Extending these notions to bipolar soft topological spaces is crucial for analyzing systems involving both positive and negative ...
Bekas S. M.Taher, Baravan A. Asaad
doaj