Results 81 to 90 of about 417,817 (243)

MHD triple diffusion due to the impulsive flow of micropolar nanofluids around a cone: Mangler's transformations and ANN analyses

Propulsion and Power Research
An implicit finite difference (FD) and artificial neural network (ANN) techniques are applied to study the triple diffusion and non-linear mixed convection flow around a vertical cone.
Z.Z. Rashed, Sameh E. Ahmed
doaj   +1 more source

Alteration Mechanisms and Classification Criteria of Hercynian Mid-term Granite in the North Tianshan Mountains [PDF]

长江科学院院报
[Objective] This study aims to address the limitations of traditional quantitative classification methods for altered granites, which often lead to coarse grade divisions and significant discrepancies in rock degradation between adjacent grades. Focusing
CHEN Li-xiang, DING Xiu-li, HUANG Shu-ling, HUANG Kang
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Monsoonal imprint on late Quaternary landscapes of the Rub’ al Khali Desert

Communications Earth & Environment
Abundant geomorphological, biological, and isotopic records show that Arabia repeatedly underwent significant climate-driven environmental changes during late Quaternary humid periods.
Abdallah S. Zaki, Antoine Delaunay, Guillaume Baby, Negar Haghipour, Cécile Blanchet, Anne Dallmeyer, Pietro Sternai, Sam Woor, Omar Wani, Hany Khalil, Mathieu Schuster, Michael Petraglia, Florence Sylvestre, Giovan Peyrotty, Mohamed Ali, Frans Van Buchem, Abdulkader M. Afifi, Sébastien Castelltort   +17 more
doaj   +1 more source

Triplectic Quantization: A Geometrically Covariant Description of the Sp(2)-symmetric Lagrangian Formalism

, 1995
A geometric description is given for the Sp(2) covariant version of the field-antifield quantization of general constrained systems in the Lagrangian formalism.
A.M. Semikhatov, Alfaro, Aoyama, Barnich, Batalin, Batalin, Batalin, Batalin, Batalin, Batalin, Batalin, Batalin, Batalin, Batalin, Batalin, Batalin, Batalin, Damgaard, Gelfand, Getzler, Grégoire, Grégoire, Grégoire, Hata, Henneaux, Henneaux, Hull, I.A. Batalin, Khudaverdian, Khudaverdyan, Lian, Magri, R. Marnelius, Reyman, Schwarz, Sen, Sen, Voronov   +37 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On Deformations of Pasting Diagrams [PDF]

, 2009
We adapt the work of Power to describe general, not-necessarily composable, not-necessarily commutative 2-categorical pasting diagrams and their composable and commutative parts.
Yetter, D. N.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source