Results 81 to 90 of about 6,224,992 (291)

Influence of weak layer heterogeneity and slab properties on slab tensile failure propensity and avalanche release area

, 2014
. Dry-snow slab avalanches are generally caused by a sequence of fracture processes, including failure initiation in a weak snow layer underlying a cohesive slab followed by crack propagation within the weak layer (WL) and tensile fracture through the ...
J. Gaume, G. Chambon, N. Eckert, M. Naaim, J. Schweizer   +4 more
semanticscholar   +1 more source

An inelastic homogenization framework for layered materials with planes of weakness

Computer Methods in Applied Mechanics and Engineering, 2020
Many geologic materials have a composite structure, in which macroscopic mechanical behavior is determined by the properties, shape, and heterogeneous distribution of individual constituents. In particular, sedimentary rocks commonly exhibit a layered microstructure, with distinct bedding planes that can also form planes of weakness.
Semnani, Shabnam J., White, Joshua A.
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

How the weak and strong links affect the evolution of prisoner's dilemma game

New Journal of Physics, 2019
The complex interactions between individuals are intertwined with time in multilayer networks. In this paper, we propose a prisoner’s dilemma game on a two-layered network, including the weak-link layer and the strong-link layer.
Dun Han, Xiang Li
doaj   +1 more source

Evaluating snow weak-layer failure parameters through inverse finite element modelling of shaking-platform experiments

, 2014
. Snowpack weak layers may fail due to excess stresses of various natures, caused by snowfall, skiers, explosions or strong ground motion due to earthquakes, and lead to snow avalanches. This research presents a numerical model describing the failure of "
E. Podolskiy, G. Chambon, M. Naaim, J. Gaume   +3 more
semanticscholar   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Controlled mining technology of multi-weak bedding down-dipping soft rock slope

Meikuang Anquan
Aiming at the problem of coal at the lower part of multi-weak bedding down-dipping soft rock slope, from the perspective of controllable slope deformation risk and the maximization of resource recovery, based on the analysis of geological data and weak ...
Jiao WANG, Qingdi CUI, Chengjiang LIANG, Daolong QU, Haiyang FENG, Hanquan LIU   +5 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Study on the Creep and Fracture Evolution Mechanism of Rock Mass with Weak Interlayers

Advances in Materials Science and Engineering, 2022
To study the influence of weak interlayers on the creep failure characteristics of rock masses, based on the continuous-discontinuous method (CDEM), the uniaxial compression creep experiments of rock masses containing weak layers were numerically ...
Na Zhao, Yibin Zhang, Haibin Miao, Lixin Meng   +3 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source