Results 61 to 70 of about 6,224,992 (291)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Analysis of triggering conditions and dynamic evolution of the January 2024 snow avalanche in Kanas, Xinjiang, China using numerical simulation and multi-source data

Geomatics, Natural Hazards & Risk
Snow avalanches represent a major natural hazard in high-mountainous regions, especially under extreme weather conditions. On 11 January 2024, a large snow avalanche occurred in the Kanas region of Xinjiang, China, causing severe disruptions to local ...
Yaqun Li, Qiulian Cheng, Jie Liu, Zhiwei Yang, Jie Bai, Bin Wang   +5 more
doaj   +1 more source

Low‐Temperature Eutectic Synthesis of PtTe2 with Weak Antilocalization and Controlled Layer Thinning [PDF]

Advanced Functional Materials, 2018
Metallic transition metal dichalcogenides (TMDs) have exhibited various exotic physical properties and hold the promise of novel optoelectronic and topological devices applications.
Song Hao, Junwen Zeng, T. Xu, Xin Cong, Chen-Yu Wang, Chenchen Wu, Yaoji Wang, Xiaowei Liu, Tianjun Cao, Guangxu Su, Lanxin Jia, Zhangting Wu, Qian Lin, Lili Zhang, Shengnan Yan, Mengfan Guo, Zhenlin Wang, P. Tan, Litao Sun, Zhenhua Ni, S. Liang, Xinyi Cui, F. Miao   +22 more
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Weak localization thickness measurements of Si:P delta-layers [PDF]

Applied Physics Letters, 2004
We report on our results for the characterization of Si:P delta-layers grown by low temperature molecular beam epitaxy. Our data show that the effective thickness of a delta-layer can be obtained through a weak localization analysis of electrical transport measurements performed in perpendicular and parallel magnetic fields.
Sullivan, D. F., Kane, B. E., Thompson, P. E.   +2 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Consolidated‐Undrained Shear Behavior of Diatomaceous Mudstones: Implications for Submarine Landslides

Geochemistry, Geophysics, Geosystems
Submarine landslides occur globally and have the potential to damage seafloor infrastructure and trigger tsunamis. Recently, diatomaceous weak layers have been hypothesized to play a role in triggering submarine landslides on passive continental margins ...
Wyatt Scott, Julia S. Reece
doaj   +1 more source

Dynamic Fracture Behavior of Weak Layers in Sandstone–Mudstone Interbedded Slopes: An Integrated Experimental and Numerical Simulation Study

Eng
To address stability issues induced by dynamic fracture of weak interlayers in sandstone–mudstone interbedded slopes during blasting excavation, this study investigates the Qingnian Hub diversion channel project of the Ping-Lu Canal through an integrated
Guocai Zhang, Ying Sun, Sheng Chen, Xue Liu, Xiaohang Tang, Zicheng Zhang, Nan Jiang   +6 more
doaj   +1 more source

Stability Analysis of Rock Slope with Multilayer Weak Interlayer

Advances in Civil Engineering, 2021
The existence of the weak interlayer of the rock slope changes its mechanical characteristics. To ensure the safety of the slope, it is necessary to analyze the overall stability of the slope. Taking the double-layer weak interlayer rock slope beside 318
Jinglong Li, Bo Zhang, Bin Sui
doaj   +1 more source