Results 121 to 130 of about 528,108 (265)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Application of magnetoencephalography in epilepsy

Heliyon
Magnetoencephalography (MEG) is a non-invasive neuroimaging technique that can detect whole-brain neuroelectromagnetic signals in real-time in a single measurement.
Qingyan Zhang, Chuanming Yin, Xiujie Fang, Yunwei Ou, Danyue Ma, Shabier Tuerxun   +5 more
doaj   +1 more source

Three Results on Weak Measurements

Current Science, 2015
Three recent results on weak measurements are presented. They are: i) repeated measurements on a single copy can not provide any information on it and further, that in the limit of very large such measurements, weak measurements have exactly the same characterstics as strong measurements, ii) the apparent non-invasiveness of weak measurements is \emph ...
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Measuring the Exploitation of Weaknesses in the Wild

IT Professional
Identifying the software weaknesses exploited by attacks supports efforts to reduce developer introduction of vulnerabilities and to guide security code review efforts. A weakness is a bug or fault type that can be exploited through an operation that results in a security-relevant error.
Peter Mell, Irena Bojanova, Carlos Eduardo Galhardo   +2 more
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Inter-Trial Consistency in Sensorimotor Cortex During Finger-Tapping Movements

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Optically-pumped magnetometer magnetoencephalography (OPM-MEG) is a new technology to detect neural electrophysiological signals. Inter-trial consistency (ITC) is an important indicator to characterize functional connectivity. It also provides a reliable
Hao Lu, Yong Li, Min Xiang, Yuyu Ma, Yang Gao, Xiaolin Ning   +5 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Sub-Hertz resonance by weak measurement. [PDF]

Nat Commun, 2020
Qu W, Jin S, Sun J, Jiang L, Wen J, Xiao Y.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source