Results 111 to 120 of about 860,460 (345)

Weak Target Integration Detection Based on Radar Communication Integrated Signal via Constructed Step-LFM Model [PDF]

Radioengineering
Weak target detection is a great challenging in radar field. To detect weak targets via radar communication integrated signal, a method for constructed step-LFM (CStep-LFM) signal is proposed based on quadrature amplitude modulation-orthogonal frequency ...
L. Xiao, X. Rao, W. He, H. Yi, J. Hu
doaj  

Elastic scattering of electron vortex beams in magnetic matter

, 2016
Elastic scattering of electron vortex beams on magnetic materials leads to a weak magnetic contrast due to Zeeman interaction of orbital angular momentum of the beam with magnetic fields in the sample.
Edström, Alexander, Lubk, Axel, Rusz, Ján   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Multiband Fusion GPS Weak Signal Tracking and Acquisition Based on Opportunistic Ant Clustering [PDF]

Jisuanji gongcheng, 2018
Ant cluster network architecture of multi-space-time,high-dimensional stochastic process is built based on signal detection and tracking metadata fants dustering algorithm,so that any ant individuals according to the random access signal opportunity to ...
ZHANG Junchao,ZHAO Rongxiang,HUO Ping,FENG Jing
doaj  

Information-theoretic bounds and phase transitions in clustering, sparse PCA, and submatrix localization

, 2017
We study the problem of detecting a structured, low-rank signal matrix corrupted with additive Gaussian noise. This includes clustering in a Gaussian mixture model, sparse PCA, and submatrix localization.
Banks, Jess, Moore, Cristopher, Vershynin, Roman, Verzelen, Nicolas, Xu, Jiaming   +4 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Detection of weak multi-target with adjacent frequency based on chaotic system

International Journal of Distributed Sensor Networks, 2019
As a promising technology in signal detection, the chaotic detection system can significantly improve the accuracy of weak signal detection in strong background noise.
Dawei Chen, Shuo Shi, Xuemai Gu, Byonghyo Shim, Qianyao Ren   +4 more
doaj   +1 more source