Results 91 to 100 of about 4,014,515 (278)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Weak Measurements with Entangled Probes
, 2008 Encoding the imaginary part of a weak value onto an initially entangled probe can modify its entanglement content - provided the probe observable can distinguish between states of different entropies.
Korolkova, Natalia, Menzies, David
core +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Weak measurement takes a simple form for cumulants
, 2007 A weak measurement on a system is made by coupling a pointer weakly to the system and then measuring the position of the pointer. If the initial wavefunction for the pointer is real, the mean displacement of the pointer is proportional to the so-called ...
B. Simon +6 more
core +1 more source
Weak value and the wave–particle duality [PDF]
Quantum Studies: Mathematics and Foundations, 2015 The weak value, introduced by Aharonov et al. to extend the conventional scope of physical observables in quantum mechanics, is an intriguing concept which sheds new light on quantum foundations and is also useful for precision measurement, but it poses serious questions on its physical meaning due to the unconventional features including the ...
Mori, Takuya, Tsutsui, Izumi
openaire +3 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Feasible optical weak measurements of complementary observables via a single Hamiltonian
, 2012 A general formalism for joint weak measurements of a pair of complementary observables is given. The standard process of optical three-wave mixing in a nonlinear crystal (such as in parametric down-conversion) is suitable for such tasks.
Wu, Shengjun, Żukowski, Marek
core +1 more source
Weak values as interference phenomena
Physical Review A, 2015 16 pages, 4 figures, lots of references; v2 considerably expanded for pedagogical clarity; v3 minor typos ...
openaire +4 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source