Results 51 to 60 of about 11,761 (283)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Weak contractive integral inequalities and fixed points in modular metric spaces
Journal of Inequalities and Applications, 2016 Branciari (Int. J. Math. Math. Sci. 29(9):531-536, 2002) gave an interesting supplement of Banach’s contraction principle for an integral-type inequality.
Nawab Hussain +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2011 In the present paper, we extend and generalize the result of Cho et. al. [1] by introducing the notion of weakly L-compatible and weakly M-compatible maps in a 2 non-Archimedean Menger PM ...
Gupta, V. K. +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Fractal and Fractional, 2022 The aim of this paper is to obtain some new results about common fixed points. Our results use weaker conditions than those previously used. We have relaxed the conditions for commutating pair mappings and compatible mappings of the type (A), which were ...
Penumarthy Parvateesam Murthy +5 more
doaj +1 more source
Common Fixed Point Theorems for Weakly Compatible Mappings
Rocky Mountain Journal of Mathematics, 2003 Let \((X,d)\) be a metric space, \(F\), \(G: X \multimap X\) be set-valued mappings and \(I\), \(J:X\to X\) two mappings. The author gives metric conditions which imply that there exists \(x \in X\) such that \(F(x)=G(x)=\{x\}\) and \(I(x)=J(x)=x\).
openaire +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Presic Type Fixed Point Theorem for Four Maps in Metric Spaces
Journal of Mathematics, 2016 We obtained a Presic type fixed point theorem for two pairs of jointly 2k-weakly compatible maps in metric spaces. We also have given an example to illustrate our main theorem.
K. P. R. Rao, Sk. Sadik, S. Manro
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source