Results 31 to 40 of about 9,176 (267)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Five-Dimensional Weakly Exceptional Quotient Singularities [PDF]

Proceedings of the Edinburgh Mathematical Society, 2013
AbstractA singularity is said to be weakly exceptional if it has a unique purely log terminal blow-up. This is a natural generalization of the surface singularities of types Dn, E6, E7 and E8. Since this idea was introduced, quotient singularities of this type have been classified in dimensions up to at most 4.
openaire   +3 more sources

Singularity Subtraction for Nonlinear Weakly Singular Integral Equations of the Second Kind [PDF]

, 2019
The singularity subtraction technique for computing an approximate solution of a linear weakly singular Fredholm integral equation of the second kind is generalized to the case of a nonlinear integral equation of the same kind. Convergence of the sequence of approximate solutions to the exact one is proved under mild standard hypotheses on the ...
Ahues, Mario, d'Almeida, Filomena Dias, Fernandes, Rosário, Vasconcelos, Paulo   +3 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Bernoulli Polynomials Method for Solving Integral Equations with Singular Kernel

مجلة بغداد للعلوم
There is always an interest in an effective technique to generate a numerical solution of integral equations with singular or weakly singular kernels more precisely because numerical methods have limitations.
Muna M. Mustafa, Heba A. Abd-Alrazak
doaj   +1 more source

A new technical for solving a weakly singular integro-differential equations

Journal of Taibah University for Science, 2017
In this work, we transform a weakly singular integro-differential equations with logarithmic kernel to singular integral equations of Cauchy type and we prove by regularization the existence and uniqueness of the solution of this equations.
Mostefa Nadir
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Numerical solution of a fractional order model of HIV infection of CD4+T cells.

پژوهش‌های ریاضی, 2022
In this paper we consider a fractional order model of HIV infection of  CD4+T cells and we transform this fractional order system of ordinary differential equations to a system of weakly singular integral equations. Afterwards we propose a Nystrom method
Roghayeh Katani
doaj  

Fast solvers of weakly singular integral equations of the second kind

Mathematical Modelling and Analysis, 2018
We discuss the bounds of fast solving weakly singular Fredholm integral equations of the second kind with a possible diagonal singularity of the kernel and certain boundary singularities of the derivatives of the free term when the information about the ...
Sumaira Rehman, Arvet Pedas, Gennadi Vainikko   +2 more
doaj   +1 more source