Results 41 to 50 of about 537,126 (291)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Bernoulli Polynomials Method for Solving Integral Equations with Singular Kernel

مجلة بغداد للعلوم
There is always an interest in an effective technique to generate a numerical solution of integral equations with singular or weakly singular kernels more precisely because numerical methods have limitations.
Muna M. Mustafa, Heba A. Abd-Alrazak
doaj   +1 more source

Five-Dimensional Weakly Exceptional Quotient Singularities [PDF]

Proceedings of the Edinburgh Mathematical Society, 2013
AbstractA singularity is said to be weakly exceptional if it has a unique purely log terminal blow-up. This is a natural generalization of the surface singularities of types Dn, E6, E7 and E8. Since this idea was introduced, quotient singularities of this type have been classified in dimensions up to at most 4.
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Numerical solution of a fractional order model of HIV infection of CD4+T cells.

پژوهش‌های ریاضی, 2022
In this paper we consider a fractional order model of HIV infection of  CD4+T cells and we transform this fractional order system of ordinary differential equations to a system of weakly singular integral equations. Afterwards we propose a Nystrom method
Roghayeh Katani
doaj  

A new technical for solving a weakly singular integro-differential equations

Journal of Taibah University for Science, 2017
In this work, we transform a weakly singular integro-differential equations with logarithmic kernel to singular integral equations of Cauchy type and we prove by regularization the existence and uniqueness of the solution of this equations.
Mostefa Nadir
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Fast solvers of weakly singular integral equations of the second kind

Mathematical Modelling and Analysis, 2018
We discuss the bounds of fast solving weakly singular Fredholm integral equations of the second kind with a possible diagonal singularity of the kernel and certain boundary singularities of the derivatives of the free term when the information about the ...
Sumaira Rehman, Arvet Pedas, Gennadi Vainikko   +2 more
doaj   +1 more source

Singularity Subtraction for Nonlinear Weakly Singular Integral Equations of the Second Kind [PDF]

, 2019
The singularity subtraction technique for computing an approximate solution of a linear weakly singular Fredholm integral equation of the second kind is generalized to the case of a nonlinear integral equation of the same kind. Convergence of the sequence of approximate solutions to the exact one is proved under mild standard hypotheses on the ...
Ahues, Mario, d'Almeida, Filomena Dias, Fernandes, Rosário, Vasconcelos, Paulo   +3 more
openaire   +1 more source