Results 101 to 110 of about 471,042 (269)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Bedrest alters respiratory muscle strength in patients immobilized due to fractured femurs

open access: yesSouth African Journal of Physiotherapy, 2000
Bedrest produces decrements in the functioning of all physiological systems. Physiotherapists treat patients who are managed with Thomas splints following fractured femurs. The patients are generally compartmentally treated as orthopaedic patients.
T. Puckree, R. Moonasur, K. Govender
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Research progress on weakness based on comprehensive geriatrics assessment

open access: yesHuli yanjiu, 2017
It reviewed the definition and model of weakness and weakness index based on comprehensive geriatrics assessment,so as to carry out the correct assessment and grading for weakness in old people,and take the comprehensive health control measures to delay ...
乔玉凤, 刘学军, 杜毓锋
doaj  

Metronome-guided Rhythmic Auditory Stimulation with Visual Feedback for Fall Prevention in Elderly: A Randomised Controlled Trial [PDF]

open access: yesJournal of Clinical and Diagnostic Research
Introduction: Elderly individuals over the age of 65 years are vulnerable to falls in the community and at home. Fall prevention strategies help reduce the risk of falls by improving muscular strength and efficiency.
Abha Khisty, Zafar Azeem, Tushar Palekar
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Medical student's perspective of problem based learning (PBL) curriculum at the University of Traskei

open access: yesSouth African Family Practice, 2002
The Faculty of Health Sciences at the University of Transkei has completed the first 5 years of its problem-based community oriented teaching curriculum.
B.L. Meel
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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